Could Aspirin Be a Protective Factor and a Factor Promoting Placental Abruption?

Placental abruption is associated with deep placentation disorders and linked to preeclampsia. We aimed to clarify its association with aspirin. Because the prophylactic use of aspirin at 150-162 mg daily from 110-140 weeks prevents most cases of preterm preeclampsia, one might think that it also prevents placental abruption. However, the literature is not so clear, and aspirin may even increase this risk. Additional studies are needed, but it is certainly important to limit aspirin to women who are truly at risk of preeclampsia and consider randomized trials to evaluate the possibility of reducing or even stopping aspirin at the end of the second trimester.