Congenital Protein C Deficiency Presenting as Neonatal Purpura Fulminans: A Report of Two Cases.

Purpura fulminans (PF) is a rare, life-threatening thrombotic disorder characterized by progressive cutaneous hemorrhagic necrosis and disseminated intravascular coagulation (DIC). Neonatal PF may result from homozygous or compound heterozygous deficiencies in natural anticoagulants, such as protein C, protein S, or antithrombin III, or secondary to sepsis. Laboratory findings typically show consumptive coagulopathy with thrombocytopenia, prolonged prothrombin time (PT), activated partial thromboplastin time (aPTT), elevated international normalized ratio (INR), low fibrinogen, and high D-dimer levels. This report describes two full-term male neonates born to consanguineous parents who developed early-onset PF due to severe hereditary protein-C deficiency (activity 4-8%, below the normal neonatal range of 25-40 IU/dL or 14-42%).​ Both exhibited rapidly progressive ecchymotic lesions leading to necrosis and eschar, and despite fresh frozen plasma (FFP) transfusions, heparin, and supportive care, they succumbed to DIC and sepsis on 13 and 22 days of life, respectively. These cases contribute meaningfully to the existing literature and reinforce the importance of genetic counseling, prompt diagnosis, and strengthening neonatal critical care resources.