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DOI 10.1080/14767058.2025.2568167

Медицинская библиотека · The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2025

Hydatidiform mole incidence in Lombardy, northern Italy, 2009-2022: continued decline or plateau?

Parodi Vittorio, Cipriani Sonia, Cantarutti Anna, Franchi Matteo, Corrao Giovanni, Lazzaro Carlo, La Vecchia Carlo, Parazzini Fabio, Esposito Giovanna

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Аннотация

INTRODUCTION

Hydatidiform mole (HM) incidence has shown contrasting temporal trends across different regions.

METHODS

We analyzed HM incidence in Lombardy, Italy, from 2009 to 2022. HM cases were identified through regional registry data.

RESULTS

A total of 1,131 HM cases occurred among 1,471,567 pregnancies, averaging 77 cases per 100,000 pregnancies. A significant decline was observed between 2009 and 2015 (p = 0.01), but no consistent trend emerged over the full period (p = 0.76). HM incidence was highest in women aged ≥46 (699.1/100,000) and <20 (107.6/100,000), and among women of Asian origin (110.4/100,000).

DISCUSSION: The study suggests that diagnostic practices and demographic shifts may have influenced HM trends, while also confirming persistent ethnic and age-related risk patterns.

Для цитирования: Parodi Vittorio, Cipriani Sonia, Cantarutti Anna, Franchi Matteo, Corrao Giovanni, Lazzaro Carlo, La Vecchia Carlo, Parazzini Fabio, Esposito Giovanna. Hydatidiform mole incidence in Lombardy, northern Italy, 2009-2022: continued decline or plateau?. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 2025. DOI: 10.1080/14767058.2025.2568167.

Предметные рубрики MeSH

HumansFemaleHydatidiform MolePregnancyItalyIncidenceAdultUterine NeoplasmsYoung AdultRegistriesMiddle AgedAdolescent
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