Fetal and pediatric pathology · 2026
Dominant Role of Placental Vascular Pathology in Preterm Birth Among Placenta Previa Cases: A Clinicopathological Analysis.
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Karakus Esra, Ozan Serhat, Ozturk Agaoglu Merve, Karatas Esra, Sahin Dilek
Аннотация
BACKGROUND: Placenta previa (PP) is a major cause of preterm birth, yet the role of placental vascular pathology remains unclear. This study investigated maternal, fetal, and placental histopathological factors associated with preterm delivery in PP cases, emphasizing vascular malperfusion.
METHODS: A retrospective case-control study included 88 singleton PP pregnancies without placental invasion: 56 preterm (<37 weeks) and 32 term (≥37 weeks) deliveries. Placental pathology was evaluated per the Amsterdam criteria. Multivariable logistic regression identified predictors of preterm birth.
RESULTS: Maternal vascular malperfusion (MVM) was significantly more common in preterm cases (67.9% vs. 18.8%, p < 0.001) and was a strong independent predictor (OR = 11.08; p < 0.001). Fetal vascular malperfusion (FVM) was also more frequent (80.4% vs. 56.3%, p = 0.030), but not independently significant.
CONCLUSION: Vascular lesions, especially MVM, are key drivers of preterm birth in PP. These findings highlight the importance of placental evaluation in clinical management.
METHODS: A retrospective case-control study included 88 singleton PP pregnancies without placental invasion: 56 preterm (<37 weeks) and 32 term (≥37 weeks) deliveries. Placental pathology was evaluated per the Amsterdam criteria. Multivariable logistic regression identified predictors of preterm birth.
RESULTS: Maternal vascular malperfusion (MVM) was significantly more common in preterm cases (67.9% vs. 18.8%, p < 0.001) and was a strong independent predictor (OR = 11.08; p < 0.001). Fetal vascular malperfusion (FVM) was also more frequent (80.4% vs. 56.3%, p = 0.030), but not independently significant.
CONCLUSION: Vascular lesions, especially MVM, are key drivers of preterm birth in PP. These findings highlight the importance of placental evaluation in clinical management.