British journal of haematology · 2001
Autoimmune neutropenia in pregnant women causing neonatal neutropenia.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Kameoka J, Funato T, Miura T, Harigae H, Saito J, Yokoyama H, Takahashi S, Yamada M, Sasaki O, Imaizumi M, Takata N, Meguro K, Sasaki T
Аннотация
Autoimmune neutropenia (AIN) can occur during pregnancy. However, neonatal neutropenia occurring in an infant born to a mother with AIN has only rarely been documented. Recently, we have experienced two cases of AIN during pregnancy, both of which caused severe yet transient neonatal neutropenia (< 0.3 x 10(9)/l), probably as a result of transplacental maternal anti-neutrophil autoantibodies. The anti-neutrophil antibodies seemed to be against antigens other than NA1/NA2 because the autoantibodies did not bind to neutrophils of specific NA types selectively in the granulocyte indirect immunofluorescence test. Although AIN is a relatively uncommon disease, neonatal neutropenia caused by maternal AIN may not be quite as rare.