Circulating Intercellular Adhesion Molecule as a Novel Marker of Pulmonary Hypertension in Newborn.

BACKGROUND

IntercellularAQ1 adhesion molecules (ICAMs) are released from the endothelium in response to shear stress. Their role in persistent pulmonary hypertension (PPHN) remains un-investigated.

METHODOLOGY: Sixty neonates (30 PPHN, 30 controls) underwent serum ICAM testing and echocardiography.

RESULTS

Right and left ventricular function was depressed in PPHN cases. Tricuspid annular plane systolic excursion was reduced (Cases 8±1 vs. Controls 11±3.5). ICAM was elevated in cases (332±96 vs. 208 ±36).

CONCLUSION

ICAM is a sensitive PPHN marker. Elevated ICAM may result from endothelial damage or contribute to PPHN pathogenesis. Further studies are needed to confirm these results and explore this relationship.