Adjuvant Autologous Platelet-Rich Plasma Gel for Decreasing Blood Loss in Posterior Placenta Previa: A Case Series and Literature Review.

ABSTRACT: We reported two cases of posterior placenta previa managed with elective cesarean delivery and adjunctive autologous platelet-rich plasma (PRP) gel. Twelve milliliters of PRP gel were used to cover both the sutured implantation site and the denuded area in both cases. Case 1, gravida 1, para 0 with 37 1/7 weeks' gestation, intra- and 24-h postoperative blood loss were 400 and 10 mL, respectively, whereas the hematocrit decreased from 34.4% to 29.4%. Case 2, gravida 2, para 1, with a gestation of 37 4/7 weeks, had intra- and 24-h postoperative blood loss of 500 and 50 mL, respectively. The hematocrit changed from 32.8% to 32%. No blood transfusion was required in either case.

CONCLUSION: Adjuvant autologous PRP gel may reduce blood loss in posterior placenta previa. Further optimization of PRP preparation protocols for pregnant women, along with validation through large-scale clinical trials, is warranted to confirm their effectiveness and generalizability.