Adjuvant Autologous Platelet-Rich Plasma Gel for Decreasing Blood Loss in Posterior Placenta Previa: A Case Series and Literature Review.

ABSTRACT: We reported two cases of posterior placenta previa managed with elective cesarean delivery and adjunctive autologous platelet-rich plasma (PRP) gel. Twelve milliliters of PRP gel were used to cover both the sutured implantation site and the denuded area in both cases. Case 1, gravida 1, para 0 with 37 1/7 weeks' gestation, intra- and 24-h postoperative blood loss were 400 and 10 mL, respectively, whereas the hematocrit decreased from 34.4% to 29.4%. Case 2, gravida 2, para 1, with a gestation of 37 4/7 weeks, had intra- and 24-h postoperative blood loss of 500 and 50 mL, respectively. The hematocrit changed from 32.8% to 32%. No blood transfusion was required in either case.

CONCLUSION

Adjuvant autologous PRP gel may reduce blood loss in posterior placenta previa. Further optimization of PRP preparation protocols for pregnant women, along with validation through large-scale clinical trials, is warranted to confirm their effectiveness and generalizability.