Acta oto-laryngologica · 2023
Effects of platelet-rich fibrin and dexamethasone on nerve regeneration after acute facial-nerve injury.
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Işik Ünal Gökalp, Ensari Nuray, Sarikçioğlu Levent, Sonbay Yilmaz Nevreste Didem, Yüksel Yeşim, Senirli Rezarta Taga, Yildiz Muhammet, Selçuk Ömer Tarik, Çetinkaya Erdem Atalay, Eyigör Hülya, Gür Özer Erdem
Аннотация
BACKGROUND: Acute facial-nerve injury.
OBJECTIVE: To investigate the effects of platelet-rich fibrin (PRF) and dexamethasone on nerve regeneration.
MATERIALS AND METHODS: Thirty-six rats were randomly divided into six groups. Facial-nerve injury was created using a full-thickness incision in all groups except Group E. Next, primary anastomosis, PRF application, topical dexamethasone application, primary anastomosis with topical PRF and dexamethasone application, and no facial-nerve repair were performed in Groups A, B, C, D, and F, respectively. Clinical, functional, and structural improvements were evaluated at eight weeks.
RESULTS: The mean eye-closure movement score in Group B was significantly higher than that in Group F (p < .001). The mean whisker-movement score in Group B was significantly higher than that in Group F (p = .001). The mean amplitude of whisker movement in Group F was significantly lower than those in Groups A, B, C, and E, and the mean amplitude in Group D was significantly lower than that in Group E (p < .001). Furthermore, an improvement in nerve ultrastructure was observed in Group B.
CONCLUSION: PRF application has a positive effect on nerve recovery after anastomosis.
SIGNIFICANCE: Contribute to the literature to improve nerve regeneration.
OBJECTIVE: To investigate the effects of platelet-rich fibrin (PRF) and dexamethasone on nerve regeneration.
MATERIALS AND METHODS: Thirty-six rats were randomly divided into six groups. Facial-nerve injury was created using a full-thickness incision in all groups except Group E. Next, primary anastomosis, PRF application, topical dexamethasone application, primary anastomosis with topical PRF and dexamethasone application, and no facial-nerve repair were performed in Groups A, B, C, D, and F, respectively. Clinical, functional, and structural improvements were evaluated at eight weeks.
RESULTS: The mean eye-closure movement score in Group B was significantly higher than that in Group F (p < .001). The mean whisker-movement score in Group B was significantly higher than that in Group F (p = .001). The mean amplitude of whisker movement in Group F was significantly lower than those in Groups A, B, C, and E, and the mean amplitude in Group D was significantly lower than that in Group E (p < .001). Furthermore, an improvement in nerve ultrastructure was observed in Group B.
CONCLUSION: PRF application has a positive effect on nerve recovery after anastomosis.
SIGNIFICANCE: Contribute to the literature to improve nerve regeneration.