American journal of obstetrics & gynecology MFM · 2025
Pregnancy Characteristics and Outcomes in Monochorionic Diamniotic Twin Pregnancies Complicated by Proximal Placental Cord Insertions From a Single Center.
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Soni Shelly, Gebb Juliana S, Paidas Teefey Christina, Coleman Beverly G, Moldenhauer Julie S, Khalek Nahla
Аннотация
BACKGROUND: Proximal placental cord insertion (pPCI), defined as a ≤4 cm distance between umbilical cord insertions, is a distinct anomaly observed in monochorionic diamniotic (MCDA) twin pregnancies, characterized by the umbilical cords of both fetuses inserting in close proximity within the placental tissue. There is limited available data on the pregnancy characteristics and outcomes in monochorionic diamniotic twins with proximal placental cord insertions (pPCI).
OBJECTIVES: To investigate pregnancy characteristics in monochorionic diamniotic (MCDA) twins complicated by pPCI and compare outcomes with nonproximal PCI (nPCI) cases.
METHODS: Single center retrospective cohort study of MCDA pregnancies evaluated from 2010 to 2023. pPCI was defined as a ≤4 cm distance between cord insertions on standardized prenatal ultrasound. Maternal characteristics, prenatal diagnoses, interventions, and perinatal outcomes were compared between pPCI and nPCI groups. The primary outcome was perinatal loss, defined as no live births or survival of only 1 fetus to hospital discharge. Multivariable logistic regression was performed to identify predictors of adverse outcomes.
RESULTS: A total of 59 pregnancies with pPCI and 1319 pregnancies with nPCI were identified. The pPCI group had higher rates of selective fetal growth restriction (sFGR; 42.4% vs 26.3%, p=0.), type III sFGR (20.3% vs 8.8%, p=.009), and abnormal umbilical artery (UA) Dopplers without definitive diagnosis (11.9% vs 0.2%, p<.0001). Twin to twin transfusion syndrome (TTTS) was less common in the pPCI group (23.7% vs 48.2%, p=.0003). Intervention was performed less frequently in pPCI (45.8% vs 58.5%, p=.05), with higher use of radiofrequency ablation (RFA) (37.3% vs 17.1%, p=.0004) and lower use of laser photocoagulation (3.4% vs 38.3%, p<.0001). Overall perinatal loss did not differ significantly (25.9% vs 21.2%, p=.25), but in the intervention subgroup, the pPCI group had significantly higher rates of "no survivors to hospital discharge" (25.9% vs 11.8%, p=.04). pPCI, sFGR, and gestational age at delivery were independently associated with no survivors to hospital discharge.
CONCLUSION: Proximal cord insertion is an uncommon but clinically relevant finding in MCDA twin pregnancies, associated with a distinct prenatal phenotype. While overall perinatal loss was similar, pPCI was independently associated with adverse outcomes following intervention. Early recognition of pPCI may inform risk stratification, surveillance, and counseling in monochorionic pregnancies. Abnormal UA Dopplers in the absence of other monochorionic pathology should prompt consideration of pPCI.
OBJECTIVES: To investigate pregnancy characteristics in monochorionic diamniotic (MCDA) twins complicated by pPCI and compare outcomes with nonproximal PCI (nPCI) cases.
METHODS: Single center retrospective cohort study of MCDA pregnancies evaluated from 2010 to 2023. pPCI was defined as a ≤4 cm distance between cord insertions on standardized prenatal ultrasound. Maternal characteristics, prenatal diagnoses, interventions, and perinatal outcomes were compared between pPCI and nPCI groups. The primary outcome was perinatal loss, defined as no live births or survival of only 1 fetus to hospital discharge. Multivariable logistic regression was performed to identify predictors of adverse outcomes.
RESULTS: A total of 59 pregnancies with pPCI and 1319 pregnancies with nPCI were identified. The pPCI group had higher rates of selective fetal growth restriction (sFGR; 42.4% vs 26.3%, p=0.), type III sFGR (20.3% vs 8.8%, p=.009), and abnormal umbilical artery (UA) Dopplers without definitive diagnosis (11.9% vs 0.2%, p<.0001). Twin to twin transfusion syndrome (TTTS) was less common in the pPCI group (23.7% vs 48.2%, p=.0003). Intervention was performed less frequently in pPCI (45.8% vs 58.5%, p=.05), with higher use of radiofrequency ablation (RFA) (37.3% vs 17.1%, p=.0004) and lower use of laser photocoagulation (3.4% vs 38.3%, p<.0001). Overall perinatal loss did not differ significantly (25.9% vs 21.2%, p=.25), but in the intervention subgroup, the pPCI group had significantly higher rates of "no survivors to hospital discharge" (25.9% vs 11.8%, p=.04). pPCI, sFGR, and gestational age at delivery were independently associated with no survivors to hospital discharge.
CONCLUSION: Proximal cord insertion is an uncommon but clinically relevant finding in MCDA twin pregnancies, associated with a distinct prenatal phenotype. While overall perinatal loss was similar, pPCI was independently associated with adverse outcomes following intervention. Early recognition of pPCI may inform risk stratification, surveillance, and counseling in monochorionic pregnancies. Abnormal UA Dopplers in the absence of other monochorionic pathology should prompt consideration of pPCI.