Urologic oncology · 2026
Effect of marital status on years of life lost from metastatic bladder cancer according to sex and race/ethnicity.
СтатьяНазвание и аннотация: Перевод в очереди
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Petix Michele, Polverino Federico, Quarta Leonardo, Filzmayer Maximilian, Lee Nick J, Orlandi Filippo, Goyal Jordan A, Longo Nicola, Briganti Alberto, Chun Felix, Micali Salvatore, Shariat Shahrokh F, Marmiroli Andrea, Luzzago Stefano, Mistretta Francesco, Saad Fred, Musi Gennaro, Karakiewicz Pierre I
Аннотация
INTRODUCTION: It is unknown whether marital status affects years of life lost (YLL) in metastatic urothelial carcinoma of the urinary bladder (mUCUB), according to sex and race/ethnicity.
METHODS: Within SEER database (2004-2021), unmarried and married mUCUB patients aged 40-80 years were identified. Age- and sex-matched controls were generated (Social Security Administration life tables and Monte Carlo simulation). Years of life lost (YLL) were quantified, relative to age- and sex-matched simulated population controls.
RESULTS: In unmarried male mUCUB patients (n = 1,976), the distribution according to race/ethnicity was as follows: 1,546 Caucasians, 248 African Americans, 182 Hispanics. In unmarried female mUCUB patients (n = 998), the distribution according to race/ethnicity was as follows: 723 Caucasians, 161 African Americans, 114 Hispanics. In male mUCUB patients, unmarried status was more common in African Americans (OR 1.3, P < 0.05). YLL values in unmarried vs. married males relative to age- and sex- matched controls were 8.2 vs. 5.3 (Δ = 2.9) in Caucasians, 10.1 vs. 6.7 (Δ = 3.4) in African Americans and 8.2 vs. 7.3 (Δ = 0.9) in Hispanics. In Caucasian and African American mUCUB males, unmarried status independently predicted 1.2- fold higher CSM, but not in Hispanics. Conversely, unmarried status did not affect YLL values in females.
CONCLUSION: In males mUCUB patients, African American race/ethnicity predisposes to unmarried status. Caucasian and African American unmarried mUCUB males exhibited higher YLL values than controls. In those two groups, unmarried status independently predicts higher CSM. Conversely, in females no meaningful differences in YLL were recorded according to marital status.
METHODS: Within SEER database (2004-2021), unmarried and married mUCUB patients aged 40-80 years were identified. Age- and sex-matched controls were generated (Social Security Administration life tables and Monte Carlo simulation). Years of life lost (YLL) were quantified, relative to age- and sex-matched simulated population controls.
RESULTS: In unmarried male mUCUB patients (n = 1,976), the distribution according to race/ethnicity was as follows: 1,546 Caucasians, 248 African Americans, 182 Hispanics. In unmarried female mUCUB patients (n = 998), the distribution according to race/ethnicity was as follows: 723 Caucasians, 161 African Americans, 114 Hispanics. In male mUCUB patients, unmarried status was more common in African Americans (OR 1.3, P < 0.05). YLL values in unmarried vs. married males relative to age- and sex- matched controls were 8.2 vs. 5.3 (Δ = 2.9) in Caucasians, 10.1 vs. 6.7 (Δ = 3.4) in African Americans and 8.2 vs. 7.3 (Δ = 0.9) in Hispanics. In Caucasian and African American mUCUB males, unmarried status independently predicted 1.2- fold higher CSM, but not in Hispanics. Conversely, unmarried status did not affect YLL values in females.
CONCLUSION: In males mUCUB patients, African American race/ethnicity predisposes to unmarried status. Caucasian and African American unmarried mUCUB males exhibited higher YLL values than controls. In those two groups, unmarried status independently predicts higher CSM. Conversely, in females no meaningful differences in YLL were recorded according to marital status.