Pediatric pulmonology · 2025
Mortality Prediction in Newborns With Persistent Pulmonary Hypertension: A Comparison of Four Illness Severity Scores.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод в очереди
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Pakhathirathien Pattima, Maneenil Gunlawadee, Thatrimontrichai Anucha, Dissaneevate Supaporn, Praditaukrit Manapat
Аннотация
OBJECTIVE: This study aimed to compare the accuracy of four neonatal illness severity scores for predicting mortality in persistent pulmonary hypertension of the newborn (PPHN).
STUDY DESIGN: This retrospective study included neonates diagnosed with PPHN between 2013 and 2022. The illness severity scores of four commonly used tools were completed for each infant: the Clinical Risk Index for Babies-II (CRIB-II), the Score for Neonatal Acute Physiology-Perinatal Extension version II (SNAPPE-II) in the first 12 h after admission and maximum oxygenation index (OI) and Vasoactive-Inotropic score (VIS) during the first 24 h (OI24max and VIS24max), 48 h (OI48max and VIS48max), and 72 h (OI72max and VIS72max) after admission. We constructed a receiver operating characteristic (ROC) curve to assess the discrimination and accuracy of the scores and determine the cutoff values for predicting mortality.
RESULTS: We enrolled 146 neonates (131 survivors and 15 nonsurvivors). The CRIB-II, SNAPPE-II, maximum OI, and VIS were significantly higher in nonsurvivors than in survivors. An OI72max score of 41 showed the highest accuracy in predicting mortality (area under the ROC curve [AUC] of 0.88) with an OI48max score of 31 (AUC: 0.86) and VIS72max score of 430 (AUC: 0.80) showing good accuracy. The best CRIB-II and SNAPPE-II cutoff scores for predicting mortality were 4 (AUC: 0.74) and 32 (AUC: 0.84), respectively.
CONCLUSIONS: The most accurate illness severity score for predicting mortality was OI72max score of 41. However, the OI48max, SNAPPE-II, and VIS72max scores also showed good accuracy. Mortality prediction using these scores can guide early management and close monitoring.
STUDY DESIGN: This retrospective study included neonates diagnosed with PPHN between 2013 and 2022. The illness severity scores of four commonly used tools were completed for each infant: the Clinical Risk Index for Babies-II (CRIB-II), the Score for Neonatal Acute Physiology-Perinatal Extension version II (SNAPPE-II) in the first 12 h after admission and maximum oxygenation index (OI) and Vasoactive-Inotropic score (VIS) during the first 24 h (OI24max and VIS24max), 48 h (OI48max and VIS48max), and 72 h (OI72max and VIS72max) after admission. We constructed a receiver operating characteristic (ROC) curve to assess the discrimination and accuracy of the scores and determine the cutoff values for predicting mortality.
RESULTS: We enrolled 146 neonates (131 survivors and 15 nonsurvivors). The CRIB-II, SNAPPE-II, maximum OI, and VIS were significantly higher in nonsurvivors than in survivors. An OI72max score of 41 showed the highest accuracy in predicting mortality (area under the ROC curve [AUC] of 0.88) with an OI48max score of 31 (AUC: 0.86) and VIS72max score of 430 (AUC: 0.80) showing good accuracy. The best CRIB-II and SNAPPE-II cutoff scores for predicting mortality were 4 (AUC: 0.74) and 32 (AUC: 0.84), respectively.
CONCLUSIONS: The most accurate illness severity score for predicting mortality was OI72max score of 41. However, the OI48max, SNAPPE-II, and VIS72max scores also showed good accuracy. Mortality prediction using these scores can guide early management and close monitoring.