International journal of surgery case reports · 2025
Chemotherapy-resistant invasive mole following partial hydatidiform molar pregnancy necessitating hysterectomy for hemorrhagic complications: A rare case report.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
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Ali Banan Muhsen, Hasan Louai, Daoud Ali, Al-Janabi Moatasem Hussein
Аннотация
INTRODUCTION AND IMPORTANCE: Invasive mole is a rare subset of gestational trophoblastic neoplasia (GTN), occasionally arising from a partial molar pregnancy. If untreated, it may lead to severe complications, including uterine invasion and hemorrhage.
CASE PRESENTATION: We report a 44-year-old woman with persistent vaginal bleeding and rising β-hCG levels following the evacuation of a partial hydatidiform mole. Despite methotrexate therapy, the disease progressed, necessitating hysterectomy due to hemorrhagic complications. Histopathology confirmed an invasive mole. Postoperatively, β-hCG remained elevated, and the patient experienced recurrent bleeding and metastatic spread to the vaginal vault, requiring further surgical intervention.
CLINICAL DISCUSSION: Although progression to an invasive mole is uncommon after a partial mole, this case demonstrates the potential for aggressive behavior and resistance to first-line chemotherapy. The clinical course emphasizes the importance of close β-hCG surveillance and timely multidisciplinary intervention.
CONCLUSION: This case underlines the need for vigilant follow-up after molar evacuation, especially in patients with rising β-hCG, and highlights the role of surgery when medical treatment fails.
CASE PRESENTATION: We report a 44-year-old woman with persistent vaginal bleeding and rising β-hCG levels following the evacuation of a partial hydatidiform mole. Despite methotrexate therapy, the disease progressed, necessitating hysterectomy due to hemorrhagic complications. Histopathology confirmed an invasive mole. Postoperatively, β-hCG remained elevated, and the patient experienced recurrent bleeding and metastatic spread to the vaginal vault, requiring further surgical intervention.
CLINICAL DISCUSSION: Although progression to an invasive mole is uncommon after a partial mole, this case demonstrates the potential for aggressive behavior and resistance to first-line chemotherapy. The clinical course emphasizes the importance of close β-hCG surveillance and timely multidisciplinary intervention.
CONCLUSION: This case underlines the need for vigilant follow-up after molar evacuation, especially in patients with rising β-hCG, and highlights the role of surgery when medical treatment fails.