Preimplantation genetic testing for aneuploidy in donor egg recipients does not decrease number of embryo transfers needed to achieve live birth.

OBJECTIVE

To examine whether use of preimplantation genetic testing for aneuploidy (PGT-A) among donor oocyte recipients is associated with the number of embryo transfers (ETs) required to achieve a live birth, or time to live birth.

DESIGN

Retrospective cohort study.

SUBJECTS: Recipients at a large, academic-affiliated practice who underwent donor oocyte in vitro fertilization (IVF) from 2016-2024 and achieved at least one live birth were included. Cycles using fresh or frozen donor oocytes and resulting in fresh or frozen single ETs were eligible for analysis.

EXPOSURE: Patients who did and did not use PGT-A were compared.

MAIN OUTCOME MEASURES: The primary outcome was the number of ETs required to achieve first live birth. Secondary outcomes were days from first ET until first live birth, days from fertilization until first live birth, live birth rate after first ET, and rate of spontaneous abortion per patient and per ET.

RESULTS

The study included 629 patients who underwent 927 ETs: 312 patients (479 ETs) used PGT-A and 317 patients (448 ETs) did not. On Cox proportional hazards model, no difference was found between study groups regarding number of ETs needed to achieve first live birth (hazard ratio [HR], 0.89; 95% confidence interval [CI], 0.73-1.09). There also was no difference between groups regarding number of days from first ET to first live birth (HR, 0.93; 95% CI, 0.77-1.13) and number of days from fertilization to first live birth (HR, 1.07; 95% CI, 0.83-1.36). No association was found between PGT-A group and live birth rate for the first ET (adjusted odd ratio [aOR], 1.29, 95% CI, 0.91-1.84), or rate of spontaneous abortion per patient (aOR, 1.08, 95% CI, 0.52-2.27) or per ET (aOR, 1.23; 95% CI, 0.61-2.49).

CONCLUSION

Donor oocyte recipients can be counseled that use of PGT-A does not appear to be associated with number of transfers needed to achieve live birth or with time to live birth.