Clinical chemistry and laboratory medicine · 2007
Limits of usual biochemical alcohol markers in cord blood at term: a fetal/maternal population-based study.
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Gallot Denis, de Chazeron Ingrid, Boussiron Didier, Ughetto Sylvie, Vendittelli Françoise, Legros Franz J, Roszyk Laurence, Llorca Pierre-Michel, Lemery Didier, Sapin Vincent
Аннотация
BACKGROUND: After maternal alcohol consumption during pregnancy, many neonates affected by less apparent forms of fetal alcohol syndrome disorder (FASD) do not receive proper diagnosis or treatment. There is thus a need for laboratory markers for early detection of alcohol-exposed neonates. The aim of our study was to assess the efficiency of the usual alcohol biomarkers measured in cord blood to identify alcohol-exposed neonates immediately after birth.
METHODS: A 1-year study was conducted in the labor wards of the maternity units of the Auvergne, Central France at the time of term delivery. The patients answered an anonymous self-completion survey concerning alcohol use (Alcohol Use Disorder Identification Test; AUDIT) during their pregnancy. Aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyltransferase concentrations and the percentage of carbohydrate-deficient transferrin were measured in maternal and cord blood.
RESULTS: We collected 870 maternal-fetal sample pairs. Two cases (0.2%) of typical FASD were detected. We report a non-significant correlation between maternal and cord blood biomarkers. None of the cord blood biomarkers differed significantly between newborns of alcohol-exposed and unexposed mothers.
CONCLUSIONS: We demonstrate that the usual alcohol biomarkers are not effective in cord blood for identifying alcohol-exposed neonates.
METHODS: A 1-year study was conducted in the labor wards of the maternity units of the Auvergne, Central France at the time of term delivery. The patients answered an anonymous self-completion survey concerning alcohol use (Alcohol Use Disorder Identification Test; AUDIT) during their pregnancy. Aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyltransferase concentrations and the percentage of carbohydrate-deficient transferrin were measured in maternal and cord blood.
RESULTS: We collected 870 maternal-fetal sample pairs. Two cases (0.2%) of typical FASD were detected. We report a non-significant correlation between maternal and cord blood biomarkers. None of the cord blood biomarkers differed significantly between newborns of alcohol-exposed and unexposed mothers.
CONCLUSIONS: We demonstrate that the usual alcohol biomarkers are not effective in cord blood for identifying alcohol-exposed neonates.