Prediction of Hepatitis C Virus Perinatal Transmission in Pregnant Individuals With Hepatitis C Virus Infection.
СтатьяМногоцентровое исследованиеНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Sandoval Grecio J, Saade George R, Hughes Brenna L, Clifton Rebecca G, Reddy Uma M, Bartholomew Anna, Salazar Ashley, Chien Edward K, Tita Alan T N, Thorp John M, Metz Torri D, Wapner Ronald J, Sabharwal Vishakha, Simhan Hyagriv N, Swamy Geeta K, Heyborne Kent D, Sibai Baha M, Grobman William A, El-Sayed Yasser Y, Casey Brian M, Parry Samuel, Macones George A, Prasad Mona, for the
Eunice Kennedy Shriver
National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network
Аннотация
Our objective was to develop a prediction model for hepatitis C virus (HCV) infection perinatal transmission to improve triage for neonatal follow-up. This was a secondary analysis of HCV antibody-positive participants who were enrolled in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network multicenter observational study of HCV infection in pregnancy. Among 432 participants, the perinatal transmission rate was 6.0% (95% CI, 4.0-8.7%). The prediction model was developed and included two factors: maternal HCV RNA titer greater than 10 6 international units/mL and having had any antepartum bleeding. Using this model, the area under the curve for perinatal transmission was 0.76 (95% CI, 0.67-0.86). Probabilities of perinatal transmission of HCV infection ranged from 1.5% (a pregnant individual with HCV RNA 10 6 international units/mL or less and no antepartum bleeding) to 28.5% (a pregnant individual with an HCV RNA titer greater than 10 6 international units/mL and antepartum bleeding). Our results provide data to aid in clinical counseling of pregnant individuals with positive HCV antibodies. Additional research is needed to externally validate this prediction model.