Archives of endocrinology and metabolism · 2026
Impact of early diagnosis of overt diabetes on pregnancy outcomes: a retrospective cohort study among Brazilian women.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Reichelt Angela J, Campos Maria Amélia A, Hirakata Vânia N, Oppermann Maria Lúcia
Аннотация
OBJECTIVE: Early diagnosis of overt diabetes has not been extensively explored. We compared pregnancy outcomes of women diagnosed with overt diabetes in the first trimester (up to the 13 completed weeks) to those with a later diagnosis.
SUBJECTS AND METHODS: We evaluated women with overt diabetes and a type 2 diabetes phenotype. Pregnancy evolution (gestational weight gain, HbA1c, inpatient glycemic control) and outcomes (preeclampsia, neonatal hypoglycemia, and admission to the neonatal intensive care unit) were compared using multivariable analyses (linear regression or Poisson regression with robust variances). All models computed the early diagnosis and other specific clinically relevant outcome-related variables. Results are b (linear coefficient) or adjusted relative risk (RR) with 95% CI.
RESULTS: Of the 217 study participants, 127 (58.5%) were diagnosed in the first trimester (early diagnosis group); those with a late diagnosis presented a higher 3rd-trimester HbA1c (n = 169; b = 1.29; 0.04; 0.55, p = 0.026). Maternal inpatient care was associated with later diagnosis (n = 195; RR 1.29; 1.02; 1.63, p = 0.033) and higher initial HbA1c (n = 195; RR 1.25; 1.16; 1.35, p < 0.001). Aside from a better maternal metabolic control, early diagnosis of overt diabetes did not impact any other pregnancy outcome.
CONCLUSIONS: In the present cohort of women with overt diabetes, diagnosis before the 14 gestational week modestly improved a few maternal metabolic aspects that did not translate into better pregnancy outcomes.
SUBJECTS AND METHODS: We evaluated women with overt diabetes and a type 2 diabetes phenotype. Pregnancy evolution (gestational weight gain, HbA1c, inpatient glycemic control) and outcomes (preeclampsia, neonatal hypoglycemia, and admission to the neonatal intensive care unit) were compared using multivariable analyses (linear regression or Poisson regression with robust variances). All models computed the early diagnosis and other specific clinically relevant outcome-related variables. Results are b (linear coefficient) or adjusted relative risk (RR) with 95% CI.
RESULTS: Of the 217 study participants, 127 (58.5%) were diagnosed in the first trimester (early diagnosis group); those with a late diagnosis presented a higher 3rd-trimester HbA1c (n = 169; b = 1.29; 0.04; 0.55, p = 0.026). Maternal inpatient care was associated with later diagnosis (n = 195; RR 1.29; 1.02; 1.63, p = 0.033) and higher initial HbA1c (n = 195; RR 1.25; 1.16; 1.35, p < 0.001). Aside from a better maternal metabolic control, early diagnosis of overt diabetes did not impact any other pregnancy outcome.
CONCLUSIONS: In the present cohort of women with overt diabetes, diagnosis before the 14 gestational week modestly improved a few maternal metabolic aspects that did not translate into better pregnancy outcomes.