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Войти в исследования The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception · 2025
The CPLAN study: Clotting Parameters after medicaL AbortioN.
СтатьяНазвание и аннотация: Перевод в очереди
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J Reynolds-Wright John, Nimmo Alastair F, Anderson Julia A M, T Cameron Sharon
Аннотация
BACKGROUND: There is paucity of information on coagulation parameters throughout pregnancy, the puerperium, and post-abortion - and how these relate to venous thromboembolism (VTE) risk. Guidance for thromboprophylaxis post-abortion is guided by expert opinion and extrapolated from post-birth, with recommendations varying from 0 to 6 weeks duration.
METHODS: We conducted a study in a community abortion clinic in Edinburgh, UK March-August 2021. We recruited healthy pregnant women requesting medical abortion (<12 weeks gestation) and healthy, non-pregnant women (controls). Blood samples were taken prior to abortion and 10-14 days afterwards. Controls provided a single sample. We assessed laboratory markers of coagulation (Clauss-fibrinogen, prothrombin time, activated partial thromboplastin time, platelets) and viscoelastic measures using the ClotPro® system. We compared the control group with the pregnancy group pre- and post-abortion.
RESULTS: We recruited 45 women (24 pregnant, 21 non-pregnant). Clauss-fibrinogen was significantly elevated pre-abortion compared to controls (3.4 g/L vs 2.8 g/L, p = 0.04), although remained within normal range. Two viscoelastic measures showed pro-coagulant changes, one pre-abortion and one post-abortion compared to controls. The absolute differences were small and remained within normal ranges.
CONCLUSION: There were minimal differences in measures of coagulation in first trimester pregnancy, that largely resolved 10-14 days after medical abortion. Shorter courses of thromboprophylaxis might be sufficient compared to post-birth for those at high risk of VTE.
METHODS: We conducted a study in a community abortion clinic in Edinburgh, UK March-August 2021. We recruited healthy pregnant women requesting medical abortion (<12 weeks gestation) and healthy, non-pregnant women (controls). Blood samples were taken prior to abortion and 10-14 days afterwards. Controls provided a single sample. We assessed laboratory markers of coagulation (Clauss-fibrinogen, prothrombin time, activated partial thromboplastin time, platelets) and viscoelastic measures using the ClotPro® system. We compared the control group with the pregnancy group pre- and post-abortion.
RESULTS: We recruited 45 women (24 pregnant, 21 non-pregnant). Clauss-fibrinogen was significantly elevated pre-abortion compared to controls (3.4 g/L vs 2.8 g/L, p = 0.04), although remained within normal range. Two viscoelastic measures showed pro-coagulant changes, one pre-abortion and one post-abortion compared to controls. The absolute differences were small and remained within normal ranges.
CONCLUSION: There were minimal differences in measures of coagulation in first trimester pregnancy, that largely resolved 10-14 days after medical abortion. Shorter courses of thromboprophylaxis might be sufficient compared to post-birth for those at high risk of VTE.