Journal of the American Nutrition Association · 2026
Assessment of Pumpkin Seed Oil as Natural Adjunct for Hormonal Regulation in Male Gynecomastia: Clinical Insights and Outcomes.
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Jayaraj Jamuna, Thankam V S Rani
Аннотация
OBJECTIVE: This research aimed to evaluate the effectiveness of pumpkin seed oil supplementation in men with early-stage gynecomastia. The research focused on determining whether pumpkin seed oil, rich in omega-3 fatty acids, phytosterols, and zinc, is associated with improved improve hormonal balance by influencing serum testosterone and estradiol levels. The study also assessed its impact on gynecomastia-related clinical symptoms and the safety of supplementation.
METHODS: Men aged 18-50 years with early-stage gynecomastia and stable lifestyle and dietary habits are included, while individuals with major comorbidities or pumpkin-related allergies are excluded. Participants received standardized pumpkin seed oil supplementation for several weeks. Serum hormone levels, including testosterone and estradiol, are measured before and after the intervention. Clinical breast symptoms are evaluated using severity scores, and safety is assessed through clinical observation and participant self-reports.
RESULTS: Pumpkin seed oil supplementation increased testosterone levels from 513 ± 35 to 539 ± 35 ng/dL (+5.07%) and decreased estradiol levels from 30.8 ± 3.5 to 26.4 ± 3.0 pg/mL (-14.16%). Clinical symptom severity improved, with scores reducing from 2.5-3.0 to approximately 1.2. Side effects are minimal, with 85% of participants reporting no adverse effects.
CONCLUSION: Pumpkin seed oil demonstrated beneficial effects on hormonal regulation by increasing testosterone and reducing estradiol levels, suggesting its potential as a safe natural adjunct for managing hormone-related gynecomastia.
METHODS: Men aged 18-50 years with early-stage gynecomastia and stable lifestyle and dietary habits are included, while individuals with major comorbidities or pumpkin-related allergies are excluded. Participants received standardized pumpkin seed oil supplementation for several weeks. Serum hormone levels, including testosterone and estradiol, are measured before and after the intervention. Clinical breast symptoms are evaluated using severity scores, and safety is assessed through clinical observation and participant self-reports.
RESULTS: Pumpkin seed oil supplementation increased testosterone levels from 513 ± 35 to 539 ± 35 ng/dL (+5.07%) and decreased estradiol levels from 30.8 ± 3.5 to 26.4 ± 3.0 pg/mL (-14.16%). Clinical symptom severity improved, with scores reducing from 2.5-3.0 to approximately 1.2. Side effects are minimal, with 85% of participants reporting no adverse effects.
CONCLUSION: Pumpkin seed oil demonstrated beneficial effects on hormonal regulation by increasing testosterone and reducing estradiol levels, suggesting its potential as a safe natural adjunct for managing hormone-related gynecomastia.