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Войти в исследования Veterinary anaesthesia and analgesia · 2025
Effects of ketamine on the minimum anesthetic concentration of isoflurane in chickens (Gallus gallus domesticus).
СтатьяRandomized Controlled Trial, VeterinaryНазвание и аннотация: Перевод в очереди
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Escobar André, Dzikiti Brighton T, Roman Kurt, Rogers Alexandria, Maney Jill K
Аннотация
OBJECTIVE: To assess the effects of two continuous intravenous (IV) infusion dose rates of ketamine on the minimum anesthetic concentration (MAC) of isoflurane in chickens.
STUDY DESIGN: Prospective, randomized, blinded, experimental crossover design.
ANIMALS: A group of eight adult ISA Brown hens weighing 2.1 ± 0.19 kg.
METHODS: Anesthesia was induced and maintained with isoflurane in oxygen and chickens were mechanically ventilated. Body temperature and partial pressure of end-expired carbon dioxide were maintained between 40 and 41 °C and 30 and 40 mmHg (4-5.3 kPa). Isoflurane MAC was determined using electrical stimulation and the bracketing technique. Subsequently, a bolus of low (LD) or high (HD) dose ketamine (5 or 10 mg kg-1 IV) was injected into the brachial vein followed by a constant rate IV infusion (5 or 10 mg kg-1 hour-1, respectively), with a 1 week washout period between treatments. Isoflurane MAC was determined again approximately 1.5 (T1.5) and 3 hours (T3) after bolus injections. Adverse events and time to extubation were recorded. Data analyses consisted of a mixed-effects model for repeated measures (MAC data).
RESULTS: Isoflurane MAC was 1.51 ± 0.18% (mean ± standard deviation). Isoflurane MAC at T1.5 and T3 was 1.45 ± 0.16% and 1.53 ± 0.15% (LD) and 1.42 ± 0.24% and 1.46 ± 0.23% (HD). Isoflurane MAC values during LD [(T1.5) p = 0.857 and (T3) p = 0.995] and HD [(T1.5) p = 0.797 and (T3) p = 0.974] ketamine infusion were not different from baseline. Extubation times after isoflurane discontinuation was 12 ± 9 minutes for the LD and 14 ± 5 minutes for the HD treatment. Overall, four animals (both treatments) developed an obstructive mucous plug in the endotracheal tube.
CONCLUSIONS AND CLINICAL RELEVANCE: Ketamine did not change isoflurane MAC in chickens. Chickens anesthetized with isoflurane and ketamine should be monitored for endotracheal tube obstruction.
STUDY DESIGN: Prospective, randomized, blinded, experimental crossover design.
ANIMALS: A group of eight adult ISA Brown hens weighing 2.1 ± 0.19 kg.
METHODS: Anesthesia was induced and maintained with isoflurane in oxygen and chickens were mechanically ventilated. Body temperature and partial pressure of end-expired carbon dioxide were maintained between 40 and 41 °C and 30 and 40 mmHg (4-5.3 kPa). Isoflurane MAC was determined using electrical stimulation and the bracketing technique. Subsequently, a bolus of low (LD) or high (HD) dose ketamine (5 or 10 mg kg-1 IV) was injected into the brachial vein followed by a constant rate IV infusion (5 or 10 mg kg-1 hour-1, respectively), with a 1 week washout period between treatments. Isoflurane MAC was determined again approximately 1.5 (T1.5) and 3 hours (T3) after bolus injections. Adverse events and time to extubation were recorded. Data analyses consisted of a mixed-effects model for repeated measures (MAC data).
RESULTS: Isoflurane MAC was 1.51 ± 0.18% (mean ± standard deviation). Isoflurane MAC at T1.5 and T3 was 1.45 ± 0.16% and 1.53 ± 0.15% (LD) and 1.42 ± 0.24% and 1.46 ± 0.23% (HD). Isoflurane MAC values during LD [(T1.5) p = 0.857 and (T3) p = 0.995] and HD [(T1.5) p = 0.797 and (T3) p = 0.974] ketamine infusion were not different from baseline. Extubation times after isoflurane discontinuation was 12 ± 9 minutes for the LD and 14 ± 5 minutes for the HD treatment. Overall, four animals (both treatments) developed an obstructive mucous plug in the endotracheal tube.
CONCLUSIONS AND CLINICAL RELEVANCE: Ketamine did not change isoflurane MAC in chickens. Chickens anesthetized with isoflurane and ketamine should be monitored for endotracheal tube obstruction.