Relationship of amniotic-type placenta inflammation to pPROM, PROM and risk of early onset neonatal sepsis.

BACKGROUND

PROM and pPROM and early onset neonatal sepsis negatively affect the neonatal perinatal mortality and morbidity.

OBJECTIVES

The target of the work was to evaluate the relationship between chorioamnionitis, funisitis and PROM, pPROM and the risk of early onset neonatal sepsis.

METHODS

We examined 152 samples of the placenta and umbilical cord, histologically and microbiologically, in 53 women without PROM, 52 women with PROM and 47 women with pPROM.

RESULTS

We demonstrated a statistically significant relationship of chorioamnionitis and funisitis to the risk of early-onset neonatal sepsis. We demonstrated no relationship between pathological findings in the placenta and PROM or pPROM.

CONCLUSIONS

The histological findings of an amniotic-type placentitis can particularly be used for supporting or possibly excluding the diagnosis of early onset neonatal sepsis.