American journal of translational research · 2025
Effects of amniotomy combined with oxytocin on cervical ripening and neonatal outcome in patients with oligohydramnios in late pregnancy.
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Guo Ling, Hu Jie
Аннотация
OBJECTIVE: To investigate the effects of oxytocin on cervical ripening and neonatal outcome in patients with late-pregnancy oligohydramnios (LPO).
METHODS: The study retrospectively included 100 patients with LPO using propensity score matching (PSM). The patients were divided into two groups at a 1:1 ratio: the control group (amniotomy alone) and the observation group (amniotomy + oxytocin), with 50 cases in each group. General clinical data, blood and urine test results, imaging examination results, cervical assessment score (CAS), and neonatal Apgar scores were collected and compared between the two groups. Statistical analysis was performed using SPSS 26.0 software.
RESULT: Compared to the observation group, the control group had a lower induction success rate (84.0% vs. 76.0%, χ2 = 10.0, P = 0.0015), a higher mean CAS (4.08 ± 0.87 vs. 4.76 ± 0.95, t = 2.761, P = 0.008), and a higher proportion of neonates with Apgar score < 9 (2.0% vs. 14.0%, χ2 = 6.042, P = 0.017). Logistic regression analysis showed that serum ferritin level < 30 μg/L (OR = 4.25, 95% CI: 1.20-15.08, P = 0.025) and fetal chest-to-abdomen ratio (FAR) > 0.85 (OR = 5.95, 95% CI: 1.22-29.03, P = 0.028) were independent risk factors for inadequate cervical ripening.
CONCLUSION: Oxytocin is effective in inducing labor in patients with LPO. Its labor-inducing effect and effect on cervical ripening are influenced by maternal serum ferritin levels and fetal development indices.
METHODS: The study retrospectively included 100 patients with LPO using propensity score matching (PSM). The patients were divided into two groups at a 1:1 ratio: the control group (amniotomy alone) and the observation group (amniotomy + oxytocin), with 50 cases in each group. General clinical data, blood and urine test results, imaging examination results, cervical assessment score (CAS), and neonatal Apgar scores were collected and compared between the two groups. Statistical analysis was performed using SPSS 26.0 software.
RESULT: Compared to the observation group, the control group had a lower induction success rate (84.0% vs. 76.0%, χ2 = 10.0, P = 0.0015), a higher mean CAS (4.08 ± 0.87 vs. 4.76 ± 0.95, t = 2.761, P = 0.008), and a higher proportion of neonates with Apgar score < 9 (2.0% vs. 14.0%, χ2 = 6.042, P = 0.017). Logistic regression analysis showed that serum ferritin level < 30 μg/L (OR = 4.25, 95% CI: 1.20-15.08, P = 0.025) and fetal chest-to-abdomen ratio (FAR) > 0.85 (OR = 5.95, 95% CI: 1.22-29.03, P = 0.028) were independent risk factors for inadequate cervical ripening.
CONCLUSION: Oxytocin is effective in inducing labor in patients with LPO. Its labor-inducing effect and effect on cervical ripening are influenced by maternal serum ferritin levels and fetal development indices.