Wiadomosci lekarskie (Warsaw, Poland : 1960) · 2019
Peculiarities of changes in indices of calcium and zinc trace elements and matrix metalloproteinase-2 in pregnant women with perinatal infections.
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Vygivska Lyudmyla A
Аннотация
OBJECTIVE: Introduction: The role of calcium and zinc in the body is very high and diverse. Calcium performs a structural and important regulatory function, participates in key physiological and biochemical processes. One such regulation is its coordinated action with zinc, occurring in matrix metalloproteinases (MMP), which play an important role in reproductive processes. The aim: To study the peculiarities of changes in the levels of calcium, zinc indices in serum of pregnant and umbilical cord blood of newborns and MMP-2 indices in serum of pregnant, depending on the etiology of perinatal infection.
PATIENTS AND METHODS: Materials and methods: The study involved 230 pregnant and their newborns, who were divided into clinical groups depending on the pathogen of perinatal infection (PI): Group I - 60 women with viral PI; Group II - 60 women with bacterial PI; Group ІІІ - 60 women with combined PI; Group IV (control) - 50 women with a physiological course of pregnancy. The presence of PI is confirmed by the high titre of anti-infective M antibodies and low-avidity Ig G in serum and other biological fluids in pregnant women and their newborns. The study implied determination of the level of calcium and zinc in serum of peripheral blood in pregnant and cord blood of newborns, the level of MMP-2 in serum of peripheral blood in pregnant. The received data was statistically processed using STATISTICA software.
RESULTS: Results: The presence of PIs leads to the development of moderate but consistent hypocalcemia. Bacterial infection has a more pronounced negative effect than a viral infection, whereas the combined infection is most likely to affect the reduction of calcium in the blood serum of pregnant women. In the groups of patients with PI, the average zinc content in serum of pregnant and umbilical cord blood of newborns was reduced in comparison with the control group (1 μmol / l, Kruskall-Wallis test, p <0.05). In all groups of pregnant with PIs, MMP-2 level in blood was elevated with respect to Group IV parameters by about 3-4 times (Kruskall-Wallis test, p <0.05). Assessment of the decrease in the level of trace elements studied in pregnant with PIs showed a statistically significant relationship between the level of MMP-2 and the level of serum calcium in pregnant and PI in newborn (Kruskall-Wallis test, p 0.001).
CONCLUSION: Conclusions: Taking into account the fact that MMPs belong to Zn- and Ca-dependent proteolytic enzymes, it can be assumed that microelementosis and changes in the level of MMP-2 found in women are interrelated, they are complex and contribute to the creation of favorable conditions for the risk of development of PIs and other complications of the fetus.
PATIENTS AND METHODS: Materials and methods: The study involved 230 pregnant and their newborns, who were divided into clinical groups depending on the pathogen of perinatal infection (PI): Group I - 60 women with viral PI; Group II - 60 women with bacterial PI; Group ІІІ - 60 women with combined PI; Group IV (control) - 50 women with a physiological course of pregnancy. The presence of PI is confirmed by the high titre of anti-infective M antibodies and low-avidity Ig G in serum and other biological fluids in pregnant women and their newborns. The study implied determination of the level of calcium and zinc in serum of peripheral blood in pregnant and cord blood of newborns, the level of MMP-2 in serum of peripheral blood in pregnant. The received data was statistically processed using STATISTICA software.
RESULTS: Results: The presence of PIs leads to the development of moderate but consistent hypocalcemia. Bacterial infection has a more pronounced negative effect than a viral infection, whereas the combined infection is most likely to affect the reduction of calcium in the blood serum of pregnant women. In the groups of patients with PI, the average zinc content in serum of pregnant and umbilical cord blood of newborns was reduced in comparison with the control group (1 μmol / l, Kruskall-Wallis test, p <0.05). In all groups of pregnant with PIs, MMP-2 level in blood was elevated with respect to Group IV parameters by about 3-4 times (Kruskall-Wallis test, p <0.05). Assessment of the decrease in the level of trace elements studied in pregnant with PIs showed a statistically significant relationship between the level of MMP-2 and the level of serum calcium in pregnant and PI in newborn (Kruskall-Wallis test, p 0.001).
CONCLUSION: Conclusions: Taking into account the fact that MMPs belong to Zn- and Ca-dependent proteolytic enzymes, it can be assumed that microelementosis and changes in the level of MMP-2 found in women are interrelated, they are complex and contribute to the creation of favorable conditions for the risk of development of PIs and other complications of the fetus.