BMJ (Clinical research ed.) · 1993
Breast feeding and risk of breast cancer in young women. United Kingdom National Case-Control Study Group.
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Аннотация
OBJECTIVE: To investigate whether breast feeding is related to subsequent risk of breast cancer.
DESIGN: Population based case-control study designed primarily to investigate the relation between oral contraceptives and risk of breast cancer; data obtained from questionnaires administered by interviewers, general practitioner notes, and family planning clinic records.
SETTING: 11 health regions in Britain.
SUBJECTS: Women diagnosed with breast cancer before age 36 living in the defined study areas. One control per case, matched for age, was selected from the list of the case's general practitioner. 755 case-control pairs were interviewed.
MAIN OUTCOME MEASURES: Duration of breast feeding each liveborn infant; timing of return of menses; hormone use; other risk factors for breast cancer.
RESULTS: Risk of breast cancer fell with increasing duration of breast feeding (relative risk = 0.94 per three months' breast feeding; test for trend p = 0.026) and with number of babies breast fed (relative risk = 0.86; test for trend, p = 0.017). Breast feeding each baby for longer than three months conferred no additional benefit. Breast feeding was more strongly negatively associated with risk of breast cancer than duration of postpartum amenorrhoea (chi 2 test for trend, p = 0.69). Hormonal suppression of lactation was unrelated to risk of breast cancer (relative risk = 0.96 per episode of suppressed lactation; test for trend, p = 0.72).
CONCLUSIONS: These results suggest that breast feeding protects against the development of breast cancer in young women.
DESIGN: Population based case-control study designed primarily to investigate the relation between oral contraceptives and risk of breast cancer; data obtained from questionnaires administered by interviewers, general practitioner notes, and family planning clinic records.
SETTING: 11 health regions in Britain.
SUBJECTS: Women diagnosed with breast cancer before age 36 living in the defined study areas. One control per case, matched for age, was selected from the list of the case's general practitioner. 755 case-control pairs were interviewed.
MAIN OUTCOME MEASURES: Duration of breast feeding each liveborn infant; timing of return of menses; hormone use; other risk factors for breast cancer.
RESULTS: Risk of breast cancer fell with increasing duration of breast feeding (relative risk = 0.94 per three months' breast feeding; test for trend p = 0.026) and with number of babies breast fed (relative risk = 0.86; test for trend, p = 0.017). Breast feeding each baby for longer than three months conferred no additional benefit. Breast feeding was more strongly negatively associated with risk of breast cancer than duration of postpartum amenorrhoea (chi 2 test for trend, p = 0.69). Hormonal suppression of lactation was unrelated to risk of breast cancer (relative risk = 0.96 per episode of suppressed lactation; test for trend, p = 0.72).
CONCLUSIONS: These results suggest that breast feeding protects against the development of breast cancer in young women.