Global maternal mortality associated with SARS-CoV-2 infection: a systematic review and meta-analysis.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Barry Kathryn, Fernández-García Silvia, Khashaba Alya, Ruiz-Calvo Gabriel, Roncal Redin Miriam, Mahmoud Ghadir, Yap Magnus, King Yasmin, Zhou Dengyi, Mamey Massa, Shepherd-Evans Isabella, Sheikh Jameela, Lawson Heidi, Kew Tania, Ansari Kehkashan, Attarde Shruti, Banjoko Adeolu, Fraser Helen, Littmoden Megan, Rajah Tanisha, Walker Kate, O'Donoghue Keelin, van Wely Madelon, van Leeuwen Elizabeth, Kostova Elena, Kunst Heinke, Khalil Asma, Brizuela Vanessa, Kara Edna, Kim Caron Rahn, Thorson Anna, Oladapo Olufemi T, Mofenson Lynne, Bonet Mercedes, Zamora Javier, Allotey John, Thangaratinam Shakila, PregCOV-19 Living Systematic Review Consortium
Аннотация
METHODS: We searched major databases (December 2019-January 2023) including Medline, LILACS, BIREME and Embase. We included studies that reported deaths in at least 10 consecutive pregnant or recently pregnant women with confirmed SARS-CoV-2 infection and assessed the studies' risk of bias. We calculated the summary estimates of any cause of death as proportions with 95% CIs using a multilevel random-effects logistic regression model. Subgroup analyses were performed by geographical region and country income groups. We used International Statistical Classification of Diseases and Related Health Problems-Maternal Mortality to categorise the reported cause of death.
FINDINGS: From 1 326 315 citations, we included 169 studies (319 172 women with confirmed SARS-CoV-2 infection; 4253 women died). The overall rate of unspecified maternal death was 0.87% (95% CI 0.64% to 1.16%). There were significant differences between geographical regions in rates of maternal mortality, with the highest rates in Sub-Saharan Africa (3.48%; 95% CI 0.66% to 16.42%) and Latin America and the Caribbean (3.16%, 95% CI 1.53% to 6.43%). Rates of maternal mortality varied by country income groups, with the highest rates in low-income countries (4.66%, 95% CI 0.75% to 24.07%). Among women with reported cause of death, 98.6% (2,390/2,423) of deaths were attributable to COVID-19.
INTERPRETATION: Rates of deaths in pregnant and recently pregnant women with SARS-CoV-2 infection vary significantly across regions and by country income groups, with the highest burden in Sub-Saharan Africa and low-income countries. COVID-19 is the main reported cause of death.
PROSPERO REGISTRATION NUMBER: CRD42020224120.