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Войти в исследования Journal of perinatology : official journal of the California Perinatal Association · 2026
Effect modification of late surfactant treatment by patent ductus arteriosus status in ventilated preterm infants: a secondary analysis of a randomized clinical trial.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Peebles Patrick J, Eickhoff Jens C, Elgin Timothy G, Sharma Anudeepa, Bamat Nicolas A, Klein Jonathan M, McNamara Patrick J, Keller Roberta L, Kaluarachchi Dinushan C
Аннотация
OBJECTIVE: To evaluate whether the effect of late surfactant is modified by patent ductus arteriosus (PDA) status with respect to survival without bronchopulmonary dysplasia (BPD) in ventilated infants born <28 weeks' gestation.
METHODS: Secondary analysis of the Trial of Late Surfactant (TOLSURF). A formal test of interaction between PDA presence and late surfactant, with respect to survival without BPD at 36 and 40 weeks' postmenstrual age (PMA), was performed. PDA presence was defined by PDA treatment, either medical or a ligation (definition A), or PDA ligation (definition B), during or after late surfactant administration.
RESULTS: All 511 infants were included. No interaction was detected between a PDA and late surfactant for survival without BPD at 36 weeks' PMA (definition A: p = 0.41; definition B: p = 0.33), or at 40 weeks' PMA (definition A: p = 0.84; definition B: p = 0.42).
CONCLUSION: PDA presence did not modify the effect of late surfactant for survival without BPD.
METHODS: Secondary analysis of the Trial of Late Surfactant (TOLSURF). A formal test of interaction between PDA presence and late surfactant, with respect to survival without BPD at 36 and 40 weeks' postmenstrual age (PMA), was performed. PDA presence was defined by PDA treatment, either medical or a ligation (definition A), or PDA ligation (definition B), during or after late surfactant administration.
RESULTS: All 511 infants were included. No interaction was detected between a PDA and late surfactant for survival without BPD at 36 weeks' PMA (definition A: p = 0.41; definition B: p = 0.33), or at 40 weeks' PMA (definition A: p = 0.84; definition B: p = 0.42).
CONCLUSION: PDA presence did not modify the effect of late surfactant for survival without BPD.