When Sepsis Kills: A Fatal Cascade of Invasive Group A Streptococcal Sepsis.

PRESENTATION: A previously healthy 22-year-old woman presented with right groin pain, unilateral leg swelling, and dyspnoea following recent infection and minor trauma. She was hypotensive and tachycardic with a painful, mottled limb and oxygen saturations of 91%.

DIAGNOSIS: Investigations demonstrated lactic acidosis, coagulopathy, pulmonary emboli, visceral infarcts, and necrotising soft-tissue infection. Cultures confirmed Streptococcus pyogenes.

TREATMENT: Despite antibiotics, emergency surgery, and advanced life support, the patient died of multiorgan failure.

DISCUSSION: iGAS infection can mimic thromboembolic disease and requires urgent recognition.