BMJ (Clinical research ed.) · 2009
Does single application of topical chloramphenicol to high risk sutured wounds reduce incidence of wound infection after minor surgery? Prospective randomised placebo controlled double blind trial.
СтатьяМногоцентровое исследованиеРандомизированное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Heal Clare F, Buettner Petra G, Cruickshank Robert, Graham David, Browning Sheldon, Pendergast Jayne, Drobetz Herwig, Gluer Robert, Lisec Carl
Аннотация
OBJECTIVE: To determine the effectiveness of a single application of topical chloramphenicol ointment in preventing wound infection after minor dermatological surgery.
DESIGN: Prospective randomised placebo controlled double blind multicentre trial.
SETTING: Primary care in a regional centre in Queensland, Australia.
PARTICIPANTS: 972 minor surgery patients.
INTERVENTIONS: A single topical dose of chloramphenicol (n=488) or paraffin ointment (n=484; placebo).
MAIN OUTCOME MEASURE: Incidence of infection.
RESULTS: The incidence of infection in the chloramphenicol group (6.6%; 95% confidence interval 4.9 to 8.8) was significantly lower than that in the control group (11.0%; 7.9 to 15.1) (P=0.010). The absolute reduction in infection rate was 4.4%, the relative reduction was 40%, and the relative risk of wound infection in the control group was 1.7 (95% confidence interval 1.1 to 2.5) times higher than in the intervention group. The number needed to treat was 22.8.
CONCLUSION: Application of a single dose of topical chloramphenicol to high risk sutured wounds after minor surgery produces a moderate absolute reduction in infection rate that is statistically but not clinically significant. Trial registration Current Controlled Trials ISRCTN73223053.
DESIGN: Prospective randomised placebo controlled double blind multicentre trial.
SETTING: Primary care in a regional centre in Queensland, Australia.
PARTICIPANTS: 972 minor surgery patients.
INTERVENTIONS: A single topical dose of chloramphenicol (n=488) or paraffin ointment (n=484; placebo).
MAIN OUTCOME MEASURE: Incidence of infection.
RESULTS: The incidence of infection in the chloramphenicol group (6.6%; 95% confidence interval 4.9 to 8.8) was significantly lower than that in the control group (11.0%; 7.9 to 15.1) (P=0.010). The absolute reduction in infection rate was 4.4%, the relative reduction was 40%, and the relative risk of wound infection in the control group was 1.7 (95% confidence interval 1.1 to 2.5) times higher than in the intervention group. The number needed to treat was 22.8.
CONCLUSION: Application of a single dose of topical chloramphenicol to high risk sutured wounds after minor surgery produces a moderate absolute reduction in infection rate that is statistically but not clinically significant. Trial registration Current Controlled Trials ISRCTN73223053.
Предметные рубрики MeSH
Administration, TopicalAnti-Infective Agents, LocalAntibiotic ProphylaxisChloramphenicolDouble-Blind MethodDrug Resistance, MicrobialFemaleHumansMaleMiddle AgedMinimally Invasive Surgical ProceduresPseudomonas InfectionsPseudomonas aeruginosaSkin NeoplasmsStaphylococcal InfectionsStaphylococcus aureusSurgical Wound InfectionSuture TechniquesTreatment Outcome