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Войти в исследования The Journal of infection · 2025
Antibiotic chemoprophylaxis for close contacts of invasive group A streptococcus in community settings: Evidence review.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Watts Vicky, Usdin Martine, Mearkle Rachel, Sriskandan Shiranee, Cordery Rebecca, Millership Sally, Saliba Vanessa, Edmundson Claire, Pai Anjali, Brown Colin S, Balasegaram Sooria, Lamagni Theresa, Decraene Valerie, working group for the UK guidelines for the management of contacts of invasive group A streptococcus (iGAS) infection in community settings
Аннотация
OBJECTIVES: Revised UK guidelines for the management of contacts of invasive group A Streptococcus (iGAS) infection in community settings were published in December 2022. We present the findings of a narrative review which informed the public health recommendations around the provision of antibiotic chemoprophylaxis detailed in the updated guidelines.
METHODS: We conducted a literature review of studies reporting the risk of iGAS infection associated with specific risk factors.
RESULTS: There was strong epidemiological evidence for an increased risk of iGAS infection in contacts who are older individuals, post-partum women, neonates and individuals with chickenpox infection; evidence on the impact of influenza co-infection, injecting drug use or being homeless in increasing risk of iGAS infection was less robust.
CONCLUSIONS: The guidelines made recommendations to offer chemoprophylaxis to close contacts of iGAS cases who are aged ≥75 years, pregnant ≥37 weeks gestation, post-partum, neonates or those with a recent history of, or current chickenpox infection. Systematic data collection evaluating the use of chemoprophylaxis and other control measures is recommended.
METHODS: We conducted a literature review of studies reporting the risk of iGAS infection associated with specific risk factors.
RESULTS: There was strong epidemiological evidence for an increased risk of iGAS infection in contacts who are older individuals, post-partum women, neonates and individuals with chickenpox infection; evidence on the impact of influenza co-infection, injecting drug use or being homeless in increasing risk of iGAS infection was less robust.
CONCLUSIONS: The guidelines made recommendations to offer chemoprophylaxis to close contacts of iGAS cases who are aged ≥75 years, pregnant ≥37 weeks gestation, post-partum, neonates or those with a recent history of, or current chickenpox infection. Systematic data collection evaluating the use of chemoprophylaxis and other control measures is recommended.