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Войти в исследования Lasers in surgery and medicine · 2003
In vitro effects of pulsed holmium laser energy on canine uroliths and porcine cadaveric urethra.
СтатьяПоддержка службы здравоохранения СШАНазвание и аннотация: Перевод в очереди
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Wynn Victoria M, Davidson Ellen B, Higbee Russell G, Ritchey Jerry W, Ridgway Tisha D, Bartels Kenneth E, Lucroy Michael D
Аннотация
BACKGROUND AND OBJECTIVES: To assess the effect of holmium laser energy on canine uroliths and porcine urethra.
STUDY DESIGN/MATERIALS AND METHODS: Uroliths of known composition and fresh cadaveric urethra were exposed to holmium laser energy. Urolith fragmentation times and depth of urethral lesions were determined.
RESULTS: Overall mean fragmentation time was 11.8 +/- 8.01 seconds. Magnesium ammonium phosphate (MAP) and urate uroliths had significantly shorter fragmentation times compared to other uroliths. Fragmentation time of MAP uroliths irradiated with 1.2 J/pulse was significantly longer than the fragmentation time of MAP uroliths irradiated with 0.3 J/pulse. Overall mean lesion depth for urethral specimens treated with 90 degrees contact mode irradiation was significantly greater than overall mean lesion depth for specimens treated with 30 degrees non-contact mode.
CONCLUSIONS: Holmium laser energy effectively fragmented canine uroliths and caused minimal urethral damage in vitro. Dogs with urolithiasis may represent a useful animal model for developing human lithotripsy procedures.
STUDY DESIGN/MATERIALS AND METHODS: Uroliths of known composition and fresh cadaveric urethra were exposed to holmium laser energy. Urolith fragmentation times and depth of urethral lesions were determined.
RESULTS: Overall mean fragmentation time was 11.8 +/- 8.01 seconds. Magnesium ammonium phosphate (MAP) and urate uroliths had significantly shorter fragmentation times compared to other uroliths. Fragmentation time of MAP uroliths irradiated with 1.2 J/pulse was significantly longer than the fragmentation time of MAP uroliths irradiated with 0.3 J/pulse. Overall mean lesion depth for urethral specimens treated with 90 degrees contact mode irradiation was significantly greater than overall mean lesion depth for specimens treated with 30 degrees non-contact mode.
CONCLUSIONS: Holmium laser energy effectively fragmented canine uroliths and caused minimal urethral damage in vitro. Dogs with urolithiasis may represent a useful animal model for developing human lithotripsy procedures.