Metabolomic profile associated with preeclampsia and its severity: a case-control study in Colombian pregnant women.

Extra-large HDL molecules (average diameter 14.3 nm) were inversely associated with preeclampsia. Additionally, extremely (particle diameters from 75 nm upwards) and very large (average diameter 64 nm) VLDL metabolites were associated with an increased the risk of preeclampsia. These findings provide evidence of molecules of interest for establishing risk or developing potential therapeutic targets" to "Specifically, extra-large HDL molecules (average diameter 14.3 nm) were inversely associated with preeclampsia, whereas extremely large (≥75 nm) and very large (average diameter 64 nm) VLDL metabolites were associated with an increased risk. These findings highlight distinct lipoprotein-related metabolic signatures linked to preeclampsia and suggest potential targets for risk assessment and therapeutic intervention.