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DOI 10.1038/s41467-023-37200-w

Медицинская библиотека · Nature communications · 2023

Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria.

Mu Andre, Klare William P, Baines Sarah L, Ignatius Pang C N, Guérillot Romain, Harbison-Price Nichaela, Keller Nadia, Wilksch Jonathan, Nhu Nguyen Thi Khanh, Phan Minh-Duy, Keller Bernhard, Nijagal Brunda, Tull Dedreia, Dayalan Saravanan, Chua Hwa Huat Charlie, Skoneczny Dominik, Koval Jason, Hachani Abderrahman, Shah Anup D, Neha Nitika, Jadhav Snehal, Partridge Sally R, Cork Amanda J, Peters Kate, Bertolla Olivia, Brouwer Stephan, Hancock Steven J, Álvarez-Fraga Laura, De Oliveira David M P, Forde Brian, Dale Ashleigh, Mujchariyakul Warasinee, Walsh Calum J, Monk Ian, Fitzgerald Anna, Lum Mabel, Correa-Ospina Carolina, Roy Chowdhury Piklu, Parton Robert G, De Voss James, Beckett James, Monty Francois, McKinnon Jessica, Song Xiaomin, Stephen John R, Everest Marie, Bellgard Matt I, Tinning Matthew, Leeming Michael, Hocking Dianna, Jebeli Leila, Wang Nancy, Ben Zakour Nouri, Yasar Serhat A, Vecchiarelli Stefano, Russell Tonia, Zaw Thiri, Chen Tyrone, Teng Don, Kassir Zena, Lithgow Trevor, Jenney Adam, Cole Jason N, Nizet Victor, Sorrell Tania C, Peleg Anton Y, Paterson David L, Beatson Scott A, Wu Jemma, Molloy Mark P, Syme Anna E, Goode Robert J A, Hunter Adam A, Bowland Grahame, West Nicholas P, Wilkins Marc R, Djordjevic Steven P, Davies Mark R, Seemann Torsten, Howden Benjamin P, Pascovici Dana, Tyagi Sonika, Schittenhelm Ralf B, De Souza David P, McConville Malcolm J, Iredell Jonathan R, Cordwell Stuart J, Strugnell Richard A, Stinear Timothy P, Schembri Mark A, Walker Mark J

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Аннотация

Even in the setting of optimal resuscitation in high-income countries severe sepsis and septic shock have a mortality of 20-40%, with antibiotic resistance dramatically increasing this mortality risk. To develop a reference dataset enabling the identification of common bacterial targets for therapeutic intervention, we applied a standardized genomic, transcriptomic, proteomic and metabolomic technological framework to multiple clinical isolates of four sepsis-causing pathogens: Escherichia coli, Klebsiella pneumoniae species complex, Staphylococcus aureus and Streptococcus pyogenes. Exposure to human serum generated a sepsis molecular signature containing global increases in fatty acid and lipid biosynthesis and metabolism, consistent with cell envelope remodelling and nutrient adaptation for osmoprotection. In addition, acquisition of cholesterol was identified across the bacterial species. This detailed reference dataset has been established as an open resource to support discovery and translational research.

Для цитирования: Mu Andre, Klare William P, Baines Sarah L, Ignatius Pang C N, Guérillot Romain, Harbison-Price Nichaela, Keller Nadia, Wilksch Jonathan, Nhu Nguyen Thi Khanh, Phan Minh-Duy, Keller Bernhard, Nijagal Brunda, Tull Dedreia, Dayalan Saravanan, Chua Hwa Huat Charlie, Skoneczny Dominik, Koval Jason, Hachani Abderrahman, Shah Anup D, Neha Nitika, Jadhav Snehal, Partridge Sally R, Cork Amanda J, Peters Kate, Bertolla Olivia, Brouwer Stephan, Hancock Steven J, Álvarez-Fraga Laura, De Oliveira David M P, Forde Brian, Dale Ashleigh, Mujchariyakul Warasinee, Walsh Calum J, Monk Ian, Fitzgerald Anna, Lum Mabel, Correa-Ospina Carolina, Roy Chowdhury Piklu, Parton Robert G, De Voss James, Beckett James, Monty Francois, McKinnon Jessica, Song Xiaomin, Stephen John R, Everest Marie, Bellgard Matt I, Tinning Matthew, Leeming Michael, Hocking Dianna, Jebeli Leila, Wang Nancy, Ben Zakour Nouri, Yasar Serhat A, Vecchiarelli Stefano, Russell Tonia, Zaw Thiri, Chen Tyrone, Teng Don, Kassir Zena, Lithgow Trevor, Jenney Adam, Cole Jason N, Nizet Victor, Sorrell Tania C, Peleg Anton Y, Paterson David L, Beatson Scott A, Wu Jemma, Molloy Mark P, Syme Anna E, Goode Robert J A, Hunter Adam A, Bowland Grahame, West Nicholas P, Wilkins Marc R, Djordjevic Steven P, Davies Mark R, Seemann Torsten, Howden Benjamin P, Pascovici Dana, Tyagi Sonika, Schittenhelm Ralf B, De Souza David P, McConville Malcolm J, Iredell Jonathan R, Cordwell Stuart J, Strugnell Richard A, Stinear Timothy P, Schembri Mark A, Walker Mark J. Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria.. Nature communications. 2023. DOI: 10.1038/s41467-023-37200-w.

Предметные рубрики MeSH

HumansAnti-Bacterial AgentsProteomicsSepsisBacteriaStaphylococcal InfectionsEscherichia coliKlebsiellaMicrobial Sensitivity Tests
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