Journal of gynecology obstetrics and human reproduction · 2026
Evaluation of symptom improvement over time after fractional CO2 laser therapy in women with genito-urinary syndrome.
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Fabbro Laurine, Leboube Simon, Moniod Louise, Fabbro Pascale, Chauleur Céline
Аннотация
INTRODUCTION: Genitourinary Syndrome of Menopause (GSM) results from reduced estrogen levels, typically postmenopausally or after hormone-dependent cancer. It manifests with vulvovaginal (dryness, itching, burning), sexual (dyspareunia), and urinary (infections, incontinence) symptoms, severely affecting quality of life. For women who cannot use hormonal treatments or are unresponsive to them, CO₂ laser therapy offers a potential alternative.
OBJECTIVE: This study aimed to assess short- and long-term symptom improvement and sexual quality of life following CO₂ laser treatment for genito-urinary syndrome.
METHOD: A prospective, monocentric symptom improvement survey was conducted at the Saint-Étienne University Hospital between July 2019 and August 2023 with 138 patients. It was assessed using visual analogue scales (VAS) and the Female Sexual Distress Scale-Revised (FSDS-R) before treatment, one month after each session, and 10-24 months post-treatment.
RESULTS: One month after treatment, significant improvements (p < 0.0001) were noted in all GSM symptoms and sexual quality of life. These improvements remained significant at long-term follow-up (p < 0.001).
CONCLUSION: Fractional CO₂ laser therapy is an effective, durable treatment for GSM in postmenopausal women or those with hormone-dependent cancer, significantly improving urogenital quality of life.
OBJECTIVE: This study aimed to assess short- and long-term symptom improvement and sexual quality of life following CO₂ laser treatment for genito-urinary syndrome.
METHOD: A prospective, monocentric symptom improvement survey was conducted at the Saint-Étienne University Hospital between July 2019 and August 2023 with 138 patients. It was assessed using visual analogue scales (VAS) and the Female Sexual Distress Scale-Revised (FSDS-R) before treatment, one month after each session, and 10-24 months post-treatment.
RESULTS: One month after treatment, significant improvements (p < 0.0001) were noted in all GSM symptoms and sexual quality of life. These improvements remained significant at long-term follow-up (p < 0.001).
CONCLUSION: Fractional CO₂ laser therapy is an effective, durable treatment for GSM in postmenopausal women or those with hormone-dependent cancer, significantly improving urogenital quality of life.