International journal of cardiology · 2025
Anabolic-androgenic steroids on cardiac structure and function in resistance-trained athletes: A systematic review and meta-analysis.
Систематический обзорСтатьяМетаанализНазвание и аннотация: Перевод в очереди
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Cavalcante Douglas Nunes, Romariz Livia, Neto Altair, Fante Gustavo Eduardo, Júnior Silvio Marques Póvoa, Bacca Caroline Fischer
Аннотация
BACKGROUND: Anabolic-androgenic steroids (AAS) are widely used by resistance-trained athletes, but their effects on cardiac structure and function remain uncertain.
OBJECTIVE: To assess the impact of AAS on cardiac structure and function using echocardiography.
METHODS: We performed a systematic review and meta-analysis to assess the effects of AAS on echocardiographic parameters in athletes, using a random-effects model and Review Manager 5.4.1.
RESULTS: We included 35 studies with 2000 male individuals (834 resistance-trained athletes using AAS vs 754 resistance-trained non-users vs 412 sedentary controls; mean age 32 years). Compared with non-users of AAS, AAS users was associated with a decrease in left ventricular (LV) ejection fraction (MD -2.25 %; 95 % CI -3.41 to -1.09; p < 0.01), and global longitudinal strain (GLS) (MD 3.34 %; 95 % CI 2.93 to 3.76; p < 0.01). Athletes who used AAS also had an increased septal wall thickness (MD 1.24 mm; 95 % CI 0.79 to 1.69; p < 0.01), posterior wall thickness (MD 1.09 mm; 95 % CI 0.70 to 1.48; p < 0.01) and LV mass (MD 13.29 g; 95 % CI 6.25 to 20.33; p < 0.01). LV end-diastolic diameter was also higher among AAS users (MD 1.09 mm; 95 % CI 0.44 to 1.73; p < 0.01).
CONCLUSION: Among athletes, AAS was associated with a significant decrease in LV ejection fraction and GLS, alongside with increased septal and posterior wall thickness, LV mass, and end-diastolic diameter compared with athletes who do not use AAS. These findings suggest adverse cardiac remodeling in AAS users, highlighting the potential harmful cardiovascular effects of steroid use in athletes.
OBJECTIVE: To assess the impact of AAS on cardiac structure and function using echocardiography.
METHODS: We performed a systematic review and meta-analysis to assess the effects of AAS on echocardiographic parameters in athletes, using a random-effects model and Review Manager 5.4.1.
RESULTS: We included 35 studies with 2000 male individuals (834 resistance-trained athletes using AAS vs 754 resistance-trained non-users vs 412 sedentary controls; mean age 32 years). Compared with non-users of AAS, AAS users was associated with a decrease in left ventricular (LV) ejection fraction (MD -2.25 %; 95 % CI -3.41 to -1.09; p < 0.01), and global longitudinal strain (GLS) (MD 3.34 %; 95 % CI 2.93 to 3.76; p < 0.01). Athletes who used AAS also had an increased septal wall thickness (MD 1.24 mm; 95 % CI 0.79 to 1.69; p < 0.01), posterior wall thickness (MD 1.09 mm; 95 % CI 0.70 to 1.48; p < 0.01) and LV mass (MD 13.29 g; 95 % CI 6.25 to 20.33; p < 0.01). LV end-diastolic diameter was also higher among AAS users (MD 1.09 mm; 95 % CI 0.44 to 1.73; p < 0.01).
CONCLUSION: Among athletes, AAS was associated with a significant decrease in LV ejection fraction and GLS, alongside with increased septal and posterior wall thickness, LV mass, and end-diastolic diameter compared with athletes who do not use AAS. These findings suggest adverse cardiac remodeling in AAS users, highlighting the potential harmful cardiovascular effects of steroid use in athletes.