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Войти в исследования The New England journal of medicine · 2009
Emergence of ciprofloxacin-resistant Neisseria meningitidis in North America.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Wu Henry M, Harcourt Brian H, Hatcher Cynthia P, Wei Stanley C, Novak Ryan T, Wang Xin, Juni Billie A, Glennen Anita, Boxrud David J, Rainbow Jean, Schmink Susanna, Mair Raydel D, Theodore M Jordan, Sander Molly A, Miller Tracy K, Kruger Kirby, Cohn Amanda C, Clark Thomas A, Messonnier Nancy E, Mayer Leonard W, Lynfield Ruth
Аннотация
We report on three cases of meningococcal disease caused by ciprofloxacin-resistant Neisseria meningitidis, one in North Dakota and two in Minnesota. The cases were caused by the same serogroup B strain. To assess local carriage of resistant N. meningitidis, we conducted a pharyngeal-carriage survey and isolated the resistant strain from one asymptomatic carrier. Sequencing of the gene encoding subunit A of DNA gyrase (gyrA) revealed a mutation associated with fluoroquinolone resistance and suggests that the resistance was acquired by means of horizontal gene transfer with the commensal N. lactamica. In susceptibility testing of invasive N. meningitidis isolates from the Active Bacterial Core surveillance system between January 2007 and January 2008, an additional ciprofloxacin-resistant isolate was found, in this case from California. Ciprofloxacin-resistant N. meningitidis has emerged in North America.