When Is Postpartum Haemorrhage Treatment Initiated? A Nested Observational Study Within the E-MOTIVE Trial.
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Mammoliti Kristie-Marie, Althabe Fernando, Easter Christina, Devall Adam, Martin James, Funmi Adeosun Love, Yusuf Rahmatu, Abubakar Fatima, Arigbede Lolade Christiana, Mugambi JimKelly, Oyoo Polycarp, Sambusa Masumbuko, Banda Akwinata, Samuels Fawzia, Willemse Sara, Khambule Sibongile Doris, Shu'aib Hilal Mukhtar, Wakili Aminu Ado, Okore Jenipher, Mwampashi Ard, Singata-Madliki Mandisa, Arends Edna, Muller Elani, Galadanci Hadiza, Qureshi Zahida, Al-Beity Fadhlun Alwy, Hofmeyr G Justus, Fawcus Sue, Moran Neil, Gwako George, Osoti Alfred, Gallos Ioannis, Coomarasamy Arri
Аннотация
DESIGN: Nested prospective observational study.
SETTING: Hospitals in Nigeria, Kenya, Tanzania and South Africa participating in the E-MOTIVE trial.
POPULATION OR SAMPLE: Healthcare workers treating PPH.
METHODS: Between June and December 2022, we observed healthcare workers for 1-2 weeks in 39 E-MOTIVE and 39 usual care hospitals across Nigeria, Kenya, Tanzania, and South Africa managing vaginal birth and treating PPH. We descriptively compared the frequency and timing from PPH detection to treatment initiation of individual treatments and the MOTIVE bundle, between E-MOTIVE care and usual care.
RESULTS: Among 2578 observations in E-MOTIVE care hospitals, 295 (11%) PPHs were treated, and among 2834 observations in usual care hospitals, 219 (8%) PPHs were treated. In E-MOTIVE care hospitals, 97% (286/295) of women with PPH received the MOTIVE bundle, compared to 36% (79/219) in usual care. Median initiation times for the first component were similar (0 vs. 1 min), but E-MOTIVE care hospitals achieved faster initiation of all components (13 min, IQR 6-18) compared to usual care (18 min, IQR 10-25). In total, 79% (233/295) of women in E-MOTIVE care had all components initiated within 20 min, compared to 22% (48/219) in usual care.
CONCLUSIONS: Timely and comprehensive management of PPH using the MOTIVE bundle, particularly initiating all components within 15-20 min, was commonly observed in the E-MOTIVE care hospitals. Scaling up E-MOTIVE care should emphasise timely bundle initiation to strengthen PPH treatment and improve maternal health outcomes in low-and-middle-income countries.