Comparing the performance of solution-based decontaminants following exposure to toxic industrial chemicals on human skin.

The extensive use of industrial chemicals increases the likelihood of accidental or deliberate environmental release, potentially occurring in occupational, public, or military settings, with skin contact being an important route of exposure. The effectiveness of subsequent skin decontamination depends on the physicochemical properties and absorption profiles of the chemicals involved, as well as the decontamination method applied. This study assessed three solution-based decontamination approaches, hard water, 2% soapy water, and Dahlgren Decon Skin Soap against three representative compounds: chloroacetone, chloroacetonitrile, and crotonaldehyde. For all chemicals tested, statistically significant differences (p < 0.05) were more commonly observed between decontaminated and untreated samples than among the decontamination treatments themselves. These findings indicate that decontamination reliably reduces dermal permeation, even though the specific formulations did not consistently produce distinguishable differences in efficacy. These results support the practical value of prompt decontamination, highlighting that readily accessible solutions can meaningfully mitigate dermal exposure risks in real‑world chemical release scenarios.