Медицинская библиотека · Vaccine · 2008

Immunogenicity for 16 serotypes of a unique schedule of pneumococcal vaccines in a high-risk population.

Leach Amanda J, Morris Peter S, Mackenzie Grant, McDonnell Joseph, Balloch Anne, Carapetis Jonathan, Tang Mimi

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Аннотация

BACKGROUND

A unique schedule of 7-valent pneumococcal conjugate vaccine (7PCV) at 2, 4 and 6 months of age and 23-valent pneumococcal polysaccharide vaccine (23PPV) at 18 months commenced for Australian Aboriginal infants in 2001.

METHODS

Anti-capsular IgG concentrations in vaccinated and non-vaccinated (historic control) infants were determined (blinded) by (22F absorbed) ELISA.

RESULTS

One month after dose 3 of 7PCV, geometric mean concentrations (GMCs) were >1.95 microg/ml and at least 89% of infants had IgG >0.35 microg/ml to all 7PCV serotypes. One month post-23PPV, IgG to 7PCV serotypes was >0.35 microg/ml for more than 96% infants (>1.3 microg/ml for at least 70%), and IgG to non-7PCV serotypes was >0.35 microg/ml for more than 50% infants (including serotype 6A, but not 12F (17%) or 19A (44%).

CONCLUSION

7PCV and 23PPV are immunogenic in this population.

Для цитирования: Leach Amanda J, Morris Peter S, Mackenzie Grant, McDonnell Joseph, Balloch Anne, Carapetis Jonathan, Tang Mimi. Immunogenicity for 16 serotypes of a unique schedule of pneumococcal vaccines in a high-risk population.. Vaccine. 2008. DOI: 10.1016/j.vaccine.2008.05.012.

Предметные рубрики MeSH

Antibodies, Bacterial Australia Bacterial Capsules Enzyme-Linked Immunosorbent Assay Heptavalent Pneumococcal Conjugate Vaccine Humans Immunization Schedule Immunoglobulin G Infant Longitudinal Studies Meningococcal Vaccines Pneumococcal Infections Pneumococcal Vaccines

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