Canadian journal of public health = Revue canadienne de sante publique · 2008
Modifiable risk factors for invasive meningococcal disease during an Edmonton, Alberta outbreak, 1999-2002.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Honish Lance, Soskolne Colin L, Senthilselvan Ambikaipakan, Houston Stan
Аннотация
BACKGROUND: An outbreak of invasive meningococcal disease (IMD) in metro Edmonton, Alberta, Canada between December 1999 and June 2002 resulted in 84 laboratory-confirmed cases. Most cases were infected with Neisseria meningitidis serogroup C, and the highest age-specific incidence was observed in the 15-19 year age group.
METHODS: A case-control study was conducted to identify modifiable IMD risk factors among outbreak cases. Two controls were matched to each case on age and sex, and were recruited through random-digit dialing. A questionnaire was telephone-administered to 132 study participants (44 cases, 88 controls). Conditional logistic regression was utilized to calculate risk measures.
RESULTS: Multivariate analysis revealed three statistically significant risk factors: bar patronage (OR 35.2; 95% CI: 2.64-468), "rave" attendance (OR 12.8; 95% CI: 1.47-111) and maternal smoking (OR 8.88; 95% CI: 1.67-47.4). Humidifier use in the home was protective (OR 0.07; 95% CI: 0.009-0.64).
CONCLUSION: While the precision of risk estimates was low in the multivariate model, this study has identified rave attendance as an emergent IMD risk factor.
METHODS: A case-control study was conducted to identify modifiable IMD risk factors among outbreak cases. Two controls were matched to each case on age and sex, and were recruited through random-digit dialing. A questionnaire was telephone-administered to 132 study participants (44 cases, 88 controls). Conditional logistic regression was utilized to calculate risk measures.
RESULTS: Multivariate analysis revealed three statistically significant risk factors: bar patronage (OR 35.2; 95% CI: 2.64-468), "rave" attendance (OR 12.8; 95% CI: 1.47-111) and maternal smoking (OR 8.88; 95% CI: 1.67-47.4). Humidifier use in the home was protective (OR 0.07; 95% CI: 0.009-0.64).
CONCLUSION: While the precision of risk estimates was low in the multivariate model, this study has identified rave attendance as an emergent IMD risk factor.
Предметные рубрики MeSH
AdolescentAdultAge DistributionAge FactorsAlbertaAlcohol DrinkingCase-Control StudiesCrowdingDisease OutbreaksFemaleHumansIncidenceLogistic ModelsMaleMeningococcal InfectionsMultivariate AnalysisNeisseria meningitidisOdds RatioRisk AssessmentRisk FactorsSubstance-Related DisordersSurveys and Questionnaires