Outcome of idiopathic thrombocytopenic purpura in pregnancy in King Chulalongkorn Memorial Hospital.

OBJECTIVE

To study the maternal and fetal outcome of idiopathic thrombocytopenic purpura (ITP) in pregnancy.

MATERIAL AND METHOD: The medical records of women who were diagnosed to be idiopathic thrombocytopenic purpura during and before pregnancy from January 1995 to December 2004 were reviewed.

RESULTS

There were 33pregnancies from 29 ITP women as four women had two pregnancies each and one was twins. Nine cases (27.3%) were active ITP, five cases (15.2%) were relapsing ITP and eight cases (24.2%) were inactive ITP. Eleven cases (33.3%) had severe thrombocytopenia during delivery and five neonates (23.8%) had severe thrombocytopenia. There was no statistical correlation between maternal and neonatal platelet concentration (r = -0.0601). None of the mothers and fetuses had serious hemorrhagic complication such as intracranial hemorrhage.

CONCLUSION

There were low hemorrhagic risks in both mothers and infants because of the constant monitoring of multidisciplinary groups of experienced physicians, including obstetricians, hematologists, anesthesiologists and neonatologist.