Transactions of the Royal Society of Tropical Medicine and Hygiene · 2025
Association of Toll-like receptor 3 rs3775291 with Zika virus infection in Brazil.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Ayo Christiane Maria, de Moraes Amarilis Giaretta, Elpídio Laise Nayana Sala, Yamanaka Aléia Harumi Uchibaba, de Souza Victor Hugo, Lo Ré Fernanda Morselli, Pinho Tainara, Nogueira Maurício Lacerda, Brandão Cinara de Cássia, Spegiorin Lígia Consentino Junqueira Franco, Oliani Denise Cristina Moz Vaz, Zini Nathalia, Langer Ieda Bernadete Volkweis, Amaral Greicy Cezar do, de Lima Neto Quirino Alves, de Mattos Luiz Carlos, Visentainer Jeane Eliete Laguila
Аннотация
BACKGROUND: Zika virus (ZIKV) is an emergent pathogen known for the outbreak in early 2015, causing significant consequences, of which congenital ZIKV syndrome is the most severe manifestation. Toll-like receptors (TLRs) are important for the appropriate function of the innate immune response against pathogens. The presence of mutations in TLR genes can potentially result in altered susceptibility to diseases. Thus, this study aimed to investigate the influence of TLR2 rs5743708, TLR3 rs3775291, TLR4 rs4986790, TLR4 rs4986791, TLR6 rs5743810 and TLR7 rs179008 polymorphisms in ZIKV infection in a case-control study.
METHODS: The study enrolled 142 patients with ZIKV that sought medical care with ZIKV-related symptoms during the ZIKV outbreak and 142 controls. Genotyping was carried out by PCR-RFLP. Multivariate and χ2 analyses were performed to assess associations between polymorphisms and disease.
RESULTS: The dominant inheritance model revealed an increased risk for patients who were carriers of the TLR3 rs3775291 T allele. The C/T-T/T genotypes were significantly increased in patients rather than controls compared with the C/C genotype (OR=1.76, 95% CI 1.05 to 2.94; p=0.03).
CONCLUSIONS: Our data support the literature and suggest that the variant rs3775291 in TLR3 may confer susceptibility to ZIKV infection in the Brazilian population.
METHODS: The study enrolled 142 patients with ZIKV that sought medical care with ZIKV-related symptoms during the ZIKV outbreak and 142 controls. Genotyping was carried out by PCR-RFLP. Multivariate and χ2 analyses were performed to assess associations between polymorphisms and disease.
RESULTS: The dominant inheritance model revealed an increased risk for patients who were carriers of the TLR3 rs3775291 T allele. The C/T-T/T genotypes were significantly increased in patients rather than controls compared with the C/C genotype (OR=1.76, 95% CI 1.05 to 2.94; p=0.03).
CONCLUSIONS: Our data support the literature and suggest that the variant rs3775291 in TLR3 may confer susceptibility to ZIKV infection in the Brazilian population.