The Journal of clinical endocrinology and metabolism · 2026
Antithyroid drug treatment in pregnancy: a first report from the Danish PRETHYR multicenter study.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Uldall-Torp Nanna Maria, Pedersen Inge Bülow, Carlé Allan, Karmisholt Jesper Scott, Ebbehøj Eva, Grove-Laugesen Diana, Brix Thomas Heiberg, Bonnema Steen Joop, Schrijvers Bieke F, Nygaard Birte, Sigurd Lena Bjergved, Feldt-Rasmussen Ulla, Klose Marianne, Rasmussen Åse Krogh, Andersen Stig, Andersen Stine Linding
Аннотация
CONTEXT: Hyperthyroidism caused by Graves' disease (GD) should be treated in pregnancy to prevent maternal and fetal complications; however, side effects observed with antithyroid drugs (ATDs) may complicate current clinical management.
OBJECTIVE: To investigate current treatment practices for hyperthyroidism during pregnancy in Denmark and the characteristics of women receiving ATDs.
METHODS: The Danish multicenter study PRETHYR (Pregnancy Investigations on Thyroid Disease) included women with GD and women treated with ATDs in pregnancy. Maternal characteristics, preconception measurements of TSH, total T3, and TSH-receptor antibodies, and information on the clinical management and treatment before and during pregnancy, were obtained through patient questionnaires and review of the medical record.
RESULTS: Of the 121 women included, 97.5% had GD. Among the 102 women with known thyroid disease preconceptionally and no prior definitive treatment, 58.8% (n = 60) received ATDs in pregnancy. These women were more often managed by endocrinologist at conception, had lower preconception TSH, and higher total T3 and TSH-receptor antibodies compared to women not treated with ATDs. Treatment was predominantly confined to the first half of the first trimester and generally discontinued by the second or third trimester. Before conception, 59.1% of women treated with methimazole were switched to propylthiouracil, and 10.7% were switched from propylthiouracil to methimazole.
CONCLUSION: This is the first report from a multicenter study on pregnant women with GD and women treated with ATDs during pregnancy. The results provide insight into the current clinical treatment practices of hyperthyroidism in Denmark.
OBJECTIVE: To investigate current treatment practices for hyperthyroidism during pregnancy in Denmark and the characteristics of women receiving ATDs.
METHODS: The Danish multicenter study PRETHYR (Pregnancy Investigations on Thyroid Disease) included women with GD and women treated with ATDs in pregnancy. Maternal characteristics, preconception measurements of TSH, total T3, and TSH-receptor antibodies, and information on the clinical management and treatment before and during pregnancy, were obtained through patient questionnaires and review of the medical record.
RESULTS: Of the 121 women included, 97.5% had GD. Among the 102 women with known thyroid disease preconceptionally and no prior definitive treatment, 58.8% (n = 60) received ATDs in pregnancy. These women were more often managed by endocrinologist at conception, had lower preconception TSH, and higher total T3 and TSH-receptor antibodies compared to women not treated with ATDs. Treatment was predominantly confined to the first half of the first trimester and generally discontinued by the second or third trimester. Before conception, 59.1% of women treated with methimazole were switched to propylthiouracil, and 10.7% were switched from propylthiouracil to methimazole.
CONCLUSION: This is the first report from a multicenter study on pregnant women with GD and women treated with ATDs during pregnancy. The results provide insight into the current clinical treatment practices of hyperthyroidism in Denmark.