Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2026
The association among metals and changes in their concentrations in the treatment of lead poisoning in lead-exposed workers.
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Ming Xinxin, Wu Ying, Cao Jinhu, Zhang Tingrui, Cui Shouming, Yang Yanyan, Yang Yuxin, Xia Zhao-Lin, Zhang Guang-Hui, Ren Jingchao
Аннотация
BACKGROUND: High-throughput metallomics studies on lead-exposed workers are rare, and the effects of lead exposure on other metals, as well as the loss of trace metals during such treatments, remain unclear.
METHODS: We recruited 1091 lead-exposed and 75 lead-poisoned workers undergoing calcium disodium ethylenediaminetetraacetate (CaNa2EDTA) treatment. Urine samples were analyzed for 33 metals/metalloids using inductively coupled plasma mass spectrometry (ICP-MS). In lead-poisoned workers, first morning urine was collected daily over a 15-day two-course of lead elimination treatment, plasma metals were also measured pre- and post-treatment.
RESULTS: In the high-lead group, urinary concentrations of 22 elements-including Fe, Zn, Mg, Ca, Cd, U, and Cu-were significantly higher than in the low-lead group. During the two CaNa2EDTA treatment cycles, urinary concentrations of Zn, Fe, and Cd showed trends similar to those of Pb, whereas Rb showed an opposite trend; however, Cd exhibited a one-day lag effect relative to Pb. We estimated that during lead elimination therapy, additional losses of 5.11 μg/L·kg Fe, 11.71 μg/L·kg Pb, and 62.23 μg/L·kg Zn occurred per kilogram of body weight. Furthermore, plasma iron (Fe) and lead (Pb) levels decreased by 13.30% and 61.74%, respectively, following CaNa2EDTA treatment.
CONCLUSION: Metal elements showed significant associations in lead-exposed workers, which may reflect either metabolic interactions or co-exposure in the occupational setting. Preliminary evidence suggests a potential link between CaNa2EDTA treatment and increased excretion of iron (Fe) and zinc (Zn). Given this, clinicians may wish to be alert to the possibility of monitoring these elements.
METHODS: We recruited 1091 lead-exposed and 75 lead-poisoned workers undergoing calcium disodium ethylenediaminetetraacetate (CaNa2EDTA) treatment. Urine samples were analyzed for 33 metals/metalloids using inductively coupled plasma mass spectrometry (ICP-MS). In lead-poisoned workers, first morning urine was collected daily over a 15-day two-course of lead elimination treatment, plasma metals were also measured pre- and post-treatment.
RESULTS: In the high-lead group, urinary concentrations of 22 elements-including Fe, Zn, Mg, Ca, Cd, U, and Cu-were significantly higher than in the low-lead group. During the two CaNa2EDTA treatment cycles, urinary concentrations of Zn, Fe, and Cd showed trends similar to those of Pb, whereas Rb showed an opposite trend; however, Cd exhibited a one-day lag effect relative to Pb. We estimated that during lead elimination therapy, additional losses of 5.11 μg/L·kg Fe, 11.71 μg/L·kg Pb, and 62.23 μg/L·kg Zn occurred per kilogram of body weight. Furthermore, plasma iron (Fe) and lead (Pb) levels decreased by 13.30% and 61.74%, respectively, following CaNa2EDTA treatment.
CONCLUSION: Metal elements showed significant associations in lead-exposed workers, which may reflect either metabolic interactions or co-exposure in the occupational setting. Preliminary evidence suggests a potential link between CaNa2EDTA treatment and increased excretion of iron (Fe) and zinc (Zn). Given this, clinicians may wish to be alert to the possibility of monitoring these elements.