Hypertension (Dallas, Tex. : 1979) · 2026
Brain Iron in Nucleus Accumbens and Cognitive Function in Preeclampsia.
СтатьяНазвание и аннотация: Перевод в очереди
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Chen Boyao, Li Meng, Chen Tao, Zhang Qihao, Cheng Zhenyu, Huo Xinxin, Zhang Fushuai, Chen Yiwen, Liang Pengcheng, Li Yanli, Yang Linfeng, Guo Lingfei
Аннотация
BACKGROUND: Preeclampsia is associated with long-term cognitive dysfunction, potentially linked to cerebral iron deposition. This study investigated striatal iron alterations using quantitative susceptibility mapping and their relationship with cognitive function in patients with preeclampsia.
METHODS: This cross-sectional study enrolled 321 participants, including nonpregnant and pregnant healthy controls, and patients with preeclampsia. Participants underwent the Montreal Cognitive Assessment, Trail Making Test, and 1.5 T brain magnetic resonance imaging. Striatal iron content was quantified using quantitative susceptibility mapping reconstructed with a morphology-enabled dipole inversion algorithm.
RESULTS: Preeclampsia patients showed poorer executive function (Trail Making Test part [A+B]: partial η2=0.170; part B: partial η2=0.100) and elevated nucleus accumbens magnetic susceptibility (all P<0.001). Age (β=0.744, P<0.001) and hematocrit (β=0.846, P=0.011) were independently associated with iron levels. In addition, significant interactions between nucleus accumbens susceptibility values and preeclampsia status were observed for log-transformed Trail Making Test completion times (part [A+B]: interaction β=0.388, P=0.006; part B: interaction β=0.424, P=0.003), indicating that elevated iron specifically exacerbates executive vulnerability in preeclampsia.
CONCLUSIONS: Nucleus accumbens iron level is elevated in preeclampsia and correlates with executive performance. Although the cross-sectional design limits causal conclusions, these findings highlight nucleus accumbens iron deposition as a key pathological feature underlying preeclampsia-related cerebral involvement.
METHODS: This cross-sectional study enrolled 321 participants, including nonpregnant and pregnant healthy controls, and patients with preeclampsia. Participants underwent the Montreal Cognitive Assessment, Trail Making Test, and 1.5 T brain magnetic resonance imaging. Striatal iron content was quantified using quantitative susceptibility mapping reconstructed with a morphology-enabled dipole inversion algorithm.
RESULTS: Preeclampsia patients showed poorer executive function (Trail Making Test part [A+B]: partial η2=0.170; part B: partial η2=0.100) and elevated nucleus accumbens magnetic susceptibility (all P<0.001). Age (β=0.744, P<0.001) and hematocrit (β=0.846, P=0.011) were independently associated with iron levels. In addition, significant interactions between nucleus accumbens susceptibility values and preeclampsia status were observed for log-transformed Trail Making Test completion times (part [A+B]: interaction β=0.388, P=0.006; part B: interaction β=0.424, P=0.003), indicating that elevated iron specifically exacerbates executive vulnerability in preeclampsia.
CONCLUSIONS: Nucleus accumbens iron level is elevated in preeclampsia and correlates with executive performance. Although the cross-sectional design limits causal conclusions, these findings highlight nucleus accumbens iron deposition as a key pathological feature underlying preeclampsia-related cerebral involvement.