Alternatives to laboratory animals : ATLA · 2026
Key challenges for in vitro testing of oral tobacco and nicotine products for regulatory applications: Recommendations for using in vitro toxicity and disease models.
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Bishop Emma, Aleksa Katarina, Breheny Damien, Constant Samuel, Gafner Jeremie, Hurtado Sara, Hollings Michael, Keyser Brian M, Klausner Mitchell, Leverette Robert, McFadden Lynn, Miller-Holt Jacqueline, Moore Martha M, Moses Sara, Raabe Hans, Scian Mariano, Sullivan Kristie, Stankowski Leon F, Tayyarah Rana, Wieczorek Roman, Curren Rodger
Аннотация
The Institute for In Vitro Sciences (IIVS) has sponsored a series of workshops with the aim of developing recommendations for scientific and technical approaches to conducting in vitro assays to assess potential toxicity within and across tobacco and nicotine products. As well as providing a background overview of oral tobacco and nicotine products, this report focuses on the methods used to generate extracts from these products for in vitro testing, the recommended best testing practices, and suggested areas for future research. This publication was developed by a working group of workshop members, in conjunction with the ninth IIVS in vitro workshop entitled 'In Vitro Models for Testing Oral Tobacco and Nicotine Products and Continued Discussion of In Vitro Models of Toxicity and Disease', which was held in January 2024.