Journal of magnetic resonance imaging : JMRI · 2026
Quantitative Susceptibility Mapping-Based Characterization of Lesion Heterogeneity in Multiple Sclerosis.
СтатьяНазвание и аннотация: Перевод в очереди
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Asadollahzadeh Elnaz, Razmara Reza, Shahmaei Vahid, Sodaei Forough, Rezaei Ali, Hamidi Majid, Zahirmirdamadi Hossein, Lapevandani Mahsa Mohammadi, Ghafari Ali, Samadzadeh Sara, Abolfazli Roya, Moghadasi Abdorreza Naser, Ebadi Zahra, Eidi Atefeh, Navardi Samira, Heidari Hora, Azimi Amirreza, Shekarchi Babak, Moghadam Amir Eftekhari, Minagar Alireza, Sahraian Mohammad Ali
Аннотация
BACKGROUND: Quantitative susceptibility mapping (QSM) characterizes multiple sclerosis (MS) lesions through susceptibility changes related to iron and myelin. However, the prevalence, regional distribution, and relationship of QSM-defined lesion subtypes with choroid plexus alterations remain unclear.
PURPOSE: To characterize MS lesion subtypes using QSM and evaluate their prevalence, regional distribution, and associations with choroid plexus volume changes.
STUDY TYPE: Prospective longitudinal study.
POPULATION: Forty-six patients with MS (44 relapsing-remitting, 2 primary progressive; mean age, 37 ± 8 years). QSM data were available for lesion classification in 32 participants.
FIELD STRENGTH/SEQUENCE: 1.5T MRI with 3D T2-FLAIR, 3D T1-MPRAGE, and multi-echo gradient-echo sequences for QSM.
ASSESSMENT: Following whole-brain segmentation, white matter was parcellated into periventricular, juxtacortical, and deep regions. White matter lesions were segmented using the SAMSEG algorithm and classified on QSM as isointense, hypointense, hyperintense, or paramagnetic rim lesions. Lesion counts, lesion volumes, regional distribution, and associations with choroid plexus volume changes were evaluated.
STATISTICAL TESTS: Normality was assessed using the Kolmogorov-Smirnov test. Spearman correlation and Mann-Whitney U tests were used. Bonferroni correction was applied for multiple comparisons.
RESULTS: Eight hundred ninety lesions were identified: 512 isointense (57.1%), 65 hypointense (7.2%), 291 hyperintense (32.4%), and 29 paramagnetic rim lesions (3.2%). Isointense and hypointense lesions, potentially reflecting different stages of tissue repair, accounted for 64.3% of all lesions. Juxtacortical white matter was most frequently affected (43.4%), followed by subcortical (40.4%) and periventricular (16.2%) regions. Hyperintense lesion volume correlated significantly with baseline lesion volume (r = 0.71), follow-up lesion volume (r = 0.81), and total lesion volume (r = 0.87). Total lesion volume was significantly associated with bilateral choroid plexus volume changes (r = 0.515-0.595).
DATA CONCLUSION: QSM has the potential to characterize MS lesion heterogeneity by identifying distinct lesion susceptibility patterns. Total lesion volume was associated with choroid plexus volume changes.
EVIDENCE LEVEL: 2.
TECHNICAL EFFICACY: Stage 2.
PURPOSE: To characterize MS lesion subtypes using QSM and evaluate their prevalence, regional distribution, and associations with choroid plexus volume changes.
STUDY TYPE: Prospective longitudinal study.
POPULATION: Forty-six patients with MS (44 relapsing-remitting, 2 primary progressive; mean age, 37 ± 8 years). QSM data were available for lesion classification in 32 participants.
FIELD STRENGTH/SEQUENCE: 1.5T MRI with 3D T2-FLAIR, 3D T1-MPRAGE, and multi-echo gradient-echo sequences for QSM.
ASSESSMENT: Following whole-brain segmentation, white matter was parcellated into periventricular, juxtacortical, and deep regions. White matter lesions were segmented using the SAMSEG algorithm and classified on QSM as isointense, hypointense, hyperintense, or paramagnetic rim lesions. Lesion counts, lesion volumes, regional distribution, and associations with choroid plexus volume changes were evaluated.
STATISTICAL TESTS: Normality was assessed using the Kolmogorov-Smirnov test. Spearman correlation and Mann-Whitney U tests were used. Bonferroni correction was applied for multiple comparisons.
RESULTS: Eight hundred ninety lesions were identified: 512 isointense (57.1%), 65 hypointense (7.2%), 291 hyperintense (32.4%), and 29 paramagnetic rim lesions (3.2%). Isointense and hypointense lesions, potentially reflecting different stages of tissue repair, accounted for 64.3% of all lesions. Juxtacortical white matter was most frequently affected (43.4%), followed by subcortical (40.4%) and periventricular (16.2%) regions. Hyperintense lesion volume correlated significantly with baseline lesion volume (r = 0.71), follow-up lesion volume (r = 0.81), and total lesion volume (r = 0.87). Total lesion volume was significantly associated with bilateral choroid plexus volume changes (r = 0.515-0.595).
DATA CONCLUSION: QSM has the potential to characterize MS lesion heterogeneity by identifying distinct lesion susceptibility patterns. Total lesion volume was associated with choroid plexus volume changes.
EVIDENCE LEVEL: 2.
TECHNICAL EFFICACY: Stage 2.