The pattern of chromosomal abnormalities in recurrent miscarriages: a single center retrospective study.

BACKGROUND

Chromosomal abnormalities are more common in first trimester recurrent miscarriages (RM). Chromosomal anomalies affect approximately 2%-8% of couples with RM.

OBJECTIVES

Evaluate the spectrum and the frequencies of chromosomal anomalies in RM.

DESIGN

A retrospective hospital record-based descriptive study.

SETTING

A tertiary care center in Turkey.

PATIENTS AND

METHODS

We studied couples with RM between October 2020 and January 2022. Relevant family and medical history, clinical examination and the results of karyotype were statistically analyzed.

MAIN OUTCOME MEASURES: Prevalence and types of chromosomal aberrations in couples with RM. SAMPLE SİZE: 362 couples with a history of RM

RESULTS

Among the 362 couples, 14 cases (3.86%) had chromosome abnormalities. Eight cases (57.14%) were structural anomalies and six cases (42.86%) were numerical chromosomal aberrations. We found five balanced translocations (67.5%) and three Robertsonian translocations (37.5%). The prevalence of polymorphic variants was 51/362 (14.1%).

CONCLUSIONS

This study supports the conclusion that clinicians should understand the importance of chromosome analysis in these couples and direct them to karyotyping after two abortions in order to exclude the possibility of a genetic cause of RM.

LIMITATIONS: Single-center study and retrospective.

CONFLICT OF INTEREST: None.