The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2026
The influence of miR-1246 on the clinical outcomes of neonatal respiratory distress syndrome.
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Zou Shaopeng, Wang Pin, Duan Lihong, Zhang Chunye, Chen Yu, Li Guqiang
Аннотация
OBJECTIVE: Neonatal respiratory distress syndrome (NRDS) represents a serious threat to the life and health of newborns. This study aims to investigate the impact of miR-1246 on clinical outcomes in NRDS children and to evaluate its prognosis role.
METHODS: The study enrolled 98 NRDS children and 76 healthy newborns. Serum miR-1246 expression was quantified using quantitative real-time polymerase chain reaction. The prognostic impact of miR-1246 expression was evaluated using Kaplan-Meier curves and Cox regression analysis. The correlations between miR-1246 levels and the partial pressure of arterial oxygen/fraction of inspired oxygen (PaO2/FiO2, P/F), lung ultrasound score (LUS), and the Score for Neonatal Acute Physiology-Perinatal Extension (SNAPPE-II) was examined using Pearson correlation analysis. The prognostic value of miR-1246 combined with P/F, LUS, and SNAPPE-II in predicting the prognosis of NRDS children was evaluated using the receiver operating characteristic curve.
RESULTS: Serum miR-1246 was upregulated in NRDS children. NRDS children who overexpressed miR-1246 had a poorer prognosis. miR-1246, P/F, LUS, and SNAPPE-II were closely associated with poor outcomes in NRDS children. In the poor prognosis group, miR-1246, LUS, and SNAPPE-II were elevated, while P/F was reduced. miR-1246 was negatively correlated with P/F and positively correlated with LUS and SNAPPE-II. The combined application of miR-1246, P/F, LUS, and SNAPPE-II could enhance the accuracy of prognostic prediction for NRDS children.
CONCLUSION: miR-1246 is overexpressed in NRDS children and is associated with disease onset and clinical outcomes. miR-1246 may be a potential biomarker for assessing the prognosis of NRDS children.
METHODS: The study enrolled 98 NRDS children and 76 healthy newborns. Serum miR-1246 expression was quantified using quantitative real-time polymerase chain reaction. The prognostic impact of miR-1246 expression was evaluated using Kaplan-Meier curves and Cox regression analysis. The correlations between miR-1246 levels and the partial pressure of arterial oxygen/fraction of inspired oxygen (PaO2/FiO2, P/F), lung ultrasound score (LUS), and the Score for Neonatal Acute Physiology-Perinatal Extension (SNAPPE-II) was examined using Pearson correlation analysis. The prognostic value of miR-1246 combined with P/F, LUS, and SNAPPE-II in predicting the prognosis of NRDS children was evaluated using the receiver operating characteristic curve.
RESULTS: Serum miR-1246 was upregulated in NRDS children. NRDS children who overexpressed miR-1246 had a poorer prognosis. miR-1246, P/F, LUS, and SNAPPE-II were closely associated with poor outcomes in NRDS children. In the poor prognosis group, miR-1246, LUS, and SNAPPE-II were elevated, while P/F was reduced. miR-1246 was negatively correlated with P/F and positively correlated with LUS and SNAPPE-II. The combined application of miR-1246, P/F, LUS, and SNAPPE-II could enhance the accuracy of prognostic prediction for NRDS children.
CONCLUSION: miR-1246 is overexpressed in NRDS children and is associated with disease onset and clinical outcomes. miR-1246 may be a potential biomarker for assessing the prognosis of NRDS children.