Journal of occupational and environmental medicine · 2026
Exposure to Industrial Air Toxics and Risk of Breast Cancer in California: The Multiethnic Cohort Study.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Van Deventer Darcy, Park Sungshim Lani, Cheng Iona, Wu Anna H, Chen Yixin, Yang Juan, Stram Daniel O, Le Marchand Loïc, Ritz Beate, Heck Julia E
Аннотация
OBJECTIVE: Estimate breast cancer risk associated with residential industrial air pollutant exposure.
METHODS: We analyzed 53,313 women in the California Multiethnic Cohort (1993-1996) for associations between 15 industrial pollutants and breast cancer incidence. Using Environmental Protection Agency Toxic Release Inventory data, sites were linked to geocoded residential histories via quadratic decay models to estimate 5-year lagged exposures. Cox models calculated risk per interquartile range increase, stratified by race/ethnicity and hormone receptor status.
RESULTS: Increased risk was associated with dichloromethane (hazard ratio [HR] = 1.17, 95% confidence interval [CI]: 1.05-1.29), tetrachloroethylene (HR = 1.53, CI: 1.39-1.69), 1,1,1-trichloroethane (HR = 1.77, CI: 1.65-1.91), diethanolamine (HR = 1.06, CI: 0.98-1.15), lead (HR = 1.02, CI: 1.00-1.03), and methyl ethyl ketone (HR = 1.27, CI: 1.15-1.41). Formaldehyde was associated only with hormone receptor-negative tumors (HR = 1.44, CI: 1.15-1.73).
CONCLUSIONS: Residential exposure to certain industrial pollutants may increase breast cancer risk.
METHODS: We analyzed 53,313 women in the California Multiethnic Cohort (1993-1996) for associations between 15 industrial pollutants and breast cancer incidence. Using Environmental Protection Agency Toxic Release Inventory data, sites were linked to geocoded residential histories via quadratic decay models to estimate 5-year lagged exposures. Cox models calculated risk per interquartile range increase, stratified by race/ethnicity and hormone receptor status.
RESULTS: Increased risk was associated with dichloromethane (hazard ratio [HR] = 1.17, 95% confidence interval [CI]: 1.05-1.29), tetrachloroethylene (HR = 1.53, CI: 1.39-1.69), 1,1,1-trichloroethane (HR = 1.77, CI: 1.65-1.91), diethanolamine (HR = 1.06, CI: 0.98-1.15), lead (HR = 1.02, CI: 1.00-1.03), and methyl ethyl ketone (HR = 1.27, CI: 1.15-1.41). Formaldehyde was associated only with hormone receptor-negative tumors (HR = 1.44, CI: 1.15-1.73).
CONCLUSIONS: Residential exposure to certain industrial pollutants may increase breast cancer risk.