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Войти в исследования Annals of the Academy of Medicine, Singapore · 2001
46, XY female--a case report.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Leow M K, Loh K C
Аннотация
INTRODUCTION: We examine a presumptive case of complete androgen insensitivity syndrome (CAIS) with certain unusual features.
CLINICAL PICTURE: A woman with early onset osteoporosis gave a history of primary amenorrhoea and surgery for intraabdominal gonads. She subsequently defaulted follow-up and hormone replacement therapy. Endocrinological evaluation revealed hypergonadotrophic hypogonadism associated with a 46,XY karyotype.
TREATMENT: Therapy included reinforcement of the female phenotype and oestrogen replacement.
OUTCOME: There was gradual development of her secondary sexual characteristics and improvement in her bone mineral density.
CONCLUSION: Patients with CAIS need proper counselling and education according to their psychosexual make-up and sociocultural factors. The importance of long-term oestrogen replacement in a young subject post-gonadectomy cannot be overemphasized as illustrated in our case.
CLINICAL PICTURE: A woman with early onset osteoporosis gave a history of primary amenorrhoea and surgery for intraabdominal gonads. She subsequently defaulted follow-up and hormone replacement therapy. Endocrinological evaluation revealed hypergonadotrophic hypogonadism associated with a 46,XY karyotype.
TREATMENT: Therapy included reinforcement of the female phenotype and oestrogen replacement.
OUTCOME: There was gradual development of her secondary sexual characteristics and improvement in her bone mineral density.
CONCLUSION: Patients with CAIS need proper counselling and education according to their psychosexual make-up and sociocultural factors. The importance of long-term oestrogen replacement in a young subject post-gonadectomy cannot be overemphasized as illustrated in our case.